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Improving vascularization of engineered bone through the generation of pro-angiogenic effects in co-culture systems
- Source :
- Advanced Drug Delivery Reviews. 94:116-125
- Publication Year :
- 2015
- Publisher :
- Elsevier BV, 2015.
-
Abstract
- One of the major problems with bone tissue engineering is the development of a rapid vascularization after implantation to supply the growing osteoblast cells with the nutrients to grow and survive as well as to remove waste products. It has been demonstrated that capillary-like structures produced in vitro will anastomose rapidly after implantation and become functioning blood vessels. For this reason, in recent years many studies have examined a variety of human osteoblast and endothelial cell co-culture systems in order to distribute osteoblasts on all parts of the bone scaffold and at the same time provide conditions for the endothelial cells to migrate to form a network of capillary-like structures throughout the osteoblast-colonized scaffold. The movement and proliferation of endothelial cells to form capillary-like structures is known as angiogenesis and is dependent on a variety of pro-angiogenic factors. This review summarizes human 2- and 3-D co-culture models to date, the types and origins of cells used in the co-cultures and the proangiogenic factors that have been identified in the co-culture models.
- Subjects :
- Scaffold
Osteoblasts
Tissue Engineering
Tissue Scaffolds
Angiogenesis
Endothelial Cells
Neovascularization, Physiologic
Pharmaceutical Science
Bone scaffold
Osteoblast
Biology
Coculture Techniques
In vitro
Bone tissue engineering
Cell biology
Endothelial stem cell
medicine.anatomical_structure
Osteogenesis
Immunology
medicine
Humans
Cell Proliferation
Endothelial Progenitor Cells
Subjects
Details
- ISSN :
- 0169409X
- Volume :
- 94
- Database :
- OpenAIRE
- Journal :
- Advanced Drug Delivery Reviews
- Accession number :
- edsair.doi.dedup.....67c4c53d4468e5e6fee43a905114e3f0