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Impact of Revascularization on Absolute Myocardial Blood Flow as Assessed by Serial [ 15 O]H 2 O Positron Emission Tomography Imaging
- Source :
- Circulation-Cardiovascular Imaging, 11, 5, pp. e007417, Circulation-Cardiovascular Imaging, 11, e007417
- Publication Year :
- 2018
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2018.
-
Abstract
- Background: The main goal of coronary revascularization is to restore myocardial perfusion in case of ischemia, causing coronary artery disease. Yet, little is known on the effect of revascularization on absolute myocardial blood flow (MBF). Therefore, the present prospective study assesses the impact of coronary revascularization on absolute MBF as measured by [ 15 O]H 2 O positron emission tomography and fractional flow reserve (FFR) in patients with stable coronary artery disease. Methods and Results: Fifty-three patients (87% men, mean age 58.7±9.0 years) with suspected coronary artery disease were included prospectively. All patients underwent serial [ 15 O]H 2 O positron emission tomography perfusion imaging at baseline and after revascularization by either percutaneous coronary intervention (PCI) or coronary artery bypass graft surgery. FFR was routinely measured at baseline and directly post-PCI. After revascularization, regional rest and stress MBF improved from 0.77±0.16 to 0.86±0.25 mL/min/g and from 1.57±0.59 to 2.48±0.91 mL/min/g, respectively, yielding an increase in coronary flow reserve from 2.02±0.69 to 2.94±0.94 ( P P r = 0.74 and r = 0.71, respectively, P P =0.02). However, patients undergoing bypass grafting had a more advanced stage of coronary artery disease and more incomplete revascularizations. Conclusion: Successful coronary revascularization has a significant and positive impact on absolute myocardial perfusion as assessed by serial quantitative [ 15 O]H 2 O positron emission tomography. Notably, improvement of FFR after PCI was directly related to the increase in hyperemic MBF.
- Subjects :
- medicine.medical_specialty
medicine.diagnostic_test
business.industry
medicine.medical_treatment
Vascular damage Radboud Institute for Molecular Life Sciences [Radboudumc 16]
Coronary flow reserve
Percutaneous coronary intervention
Perfusion scanning
Fractional flow reserve
ta3121
030204 cardiovascular system & hematology
medicine.disease
Revascularization
030218 nuclear medicine & medical imaging
Coronary artery disease
03 medical and health sciences
Myocardial perfusion imaging
0302 clinical medicine
Internal medicine
medicine
Cardiology
Radiology, Nuclear Medicine and imaging
Cardiology and Cardiovascular Medicine
business
Perfusion
Subjects
Details
- ISSN :
- 19420080 and 19419651
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Circulation: Cardiovascular Imaging
- Accession number :
- edsair.doi.dedup.....67b42f66483cf7e91e3fdaa8ca1595bc