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Clinical correlates and heritability of cardiac mechanics: The HyperGEN study
- Source :
- International journal of cardiology. 274
- Publication Year :
- 2018
-
Abstract
- BACKGROUND: Indices of cardiac mechanics are sensitive markers of subclinical myocardial dysfunction. Improved understanding of the clinical correlates and heritability of cardiac mechanics could result in novel insight into the acquired and genetic risk factors. Therefore, we sought to determine the clinical correlates and heritability of indices of cardiac mechanics in whites and African Americans (AAs). METHODS: We examined 2058 participants stratified by race (1104 whites, 954 AA) in the Hypertension Genetic Epidemiology Network (HyperGEN), a population- and family-based study, and performed digitization of analog echocardiograms with subsequent speckle-tracking analysis. We used linear mixed effects models to determine the clinical correlates of indices of cardiac mechanics (longitudinal, circumferential, radial strain; early diastolic strain rate; and early diastolic tissue velocities). Heritability estimates for cardiac mechanics were calculated using maximum-likelihood variance component analyses in Sequential Oligogenic Linkage Analysis Routine (SOLAR), with adjustment for clinical and echocardiographic covariates. RESULTS: Several clinical characteristics and conventional echocardiographic parameters were found to be associated with speckle-tracking traits of cardiac mechanics. Male sex, blood pressure, and fasting glucose were associated with worse longitudinal strain (LS) (P
- Subjects :
- Male
medicine.medical_specialty
Future studies
Heart Ventricles
Population
Blood Pressure
030204 cardiovascular system & hematology
Ventricular Function, Left
Article
03 medical and health sciences
0302 clinical medicine
Internal medicine
Epidemiology
medicine
Prevalence
Humans
Genetic Predisposition to Disease
030212 general & internal medicine
education
Subclinical infection
education.field_of_study
business.industry
Reproducibility of Results
Signal Processing, Computer-Assisted
Stroke Volume
Heritability
Middle Aged
medicine.disease
Prognosis
Echocardiography, Doppler
United States
Blood pressure
Cross-Sectional Studies
Heart failure
Hypertension
Cardiology
Female
Cardiology and Cardiovascular Medicine
business
Cardiac mechanics
Subjects
Details
- ISSN :
- 18741754
- Volume :
- 274
- Database :
- OpenAIRE
- Journal :
- International journal of cardiology
- Accession number :
- edsair.doi.dedup.....67b3ce243326a9b203acee822502c7ea