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The Interplay between Diabetes and Alzheimer’s Disease—In the Hunt for Biomarkers
- Source :
- International Journal of Molecular Sciences, Vol 21, Iss 2744, p 2744 (2020), International Journal of Molecular Sciences
- Publication Year :
- 2020
- Publisher :
- MDPI AG, 2020.
-
Abstract
- The brain is an organ in which energy metabolism occurs most intensively and glucose is an essential and dominant energy substrate. There have been many studies in recent years suggesting a close relationship between type 2 diabetes mellitus (T2DM) and Alzheimer’s disease (AD) as they have many pathophysiological features in common. The condition of hyperglycemia exposes brain cells to the detrimental effects of glucose, increasing protein glycation and is the cause of different non-psychiatric complications. Numerous observational studies show that not only hyperglycemia but also blood glucose levels near lower fasting limits (72 to 99 mg/dL) increase the incidence of AD, regardless of whether T2DM will develop in the future. As the comorbidity of these diseases and earlier development of AD in T2DM sufferers exist, new AD biomarkers are being sought for etiopathogenetic changes associated with early neurodegenerative processes as a result of carbohydrate disorders. The S100B protein seem to be interesting in this respect as it may be a potential candidate, especially important in early diagnostics of these diseases, given that it plays a role in both carbohydrate metabolism disorders and neurodegenerative processes. It is therefore necessary to clarify the relationship between the concentration of the S100B protein and glucose and insulin levels. This paper draws attention to a valuable research objective that may in the future contribute to a better diagnosis of early neurodegenerative changes, in particular in subjects with T2DM and may be a good basis for planning experiments related to this issue as well as a more detailed explanation of the relationship between the neuropathological disturbances and changes of glucose and insulin concentrations in the brain.
- Subjects :
- medicine.medical_treatment
Carbohydrates
Energy metabolism
tau Proteins
S100 Calcium Binding Protein beta Subunit
Review
Disease
Bioinformatics
Catalysis
Inorganic Chemistry
lcsh:Chemistry
Alzheimer Disease
Diabetes mellitus
Humans
Medicine
Physical and Theoretical Chemistry
Molecular Biology
lcsh:QH301-705.5
Spectroscopy
Amyloid beta-Peptides
business.industry
Insulin
Organic Chemistry
Brain
Type 2 Diabetes Mellitus
biomarkers
General Medicine
medicine.disease
Comorbidity
Computer Science Applications
Diabetes Mellitus, Type 2
lcsh:Biology (General)
lcsh:QD1-999
Hyperglycemia
Carbohydrate Metabolism Disorder
diabetes mellitus
Observational study
business
Alzheimer’s disease
S100 proteins
Subjects
Details
- Language :
- English
- ISSN :
- 16616596 and 14220067
- Volume :
- 21
- Issue :
- 2744
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences
- Accession number :
- edsair.doi.dedup.....67b39e7b768f5880dd2c8b78cba7564b