Additional file 1 of Prognostic factors for patients with anal cancer treated with conformal radiotherapy—a systematic review

Additional file 1: Appendix A. Full search strategies employed in Embase and Medline to identify relevant papers between January 1st 2000 and June 30th 2020. Appendix B. Complete results from the study quality appraisal by both reviewers (ST and RS), including the assessment criteria used. Y: Yes. N: No. NR: Not reported. Appendix C. Complete overview of study characteristics, including the predictors tested in each study. NR: not reported. SCC: Squamous cell carcinoma. RT: radiotherapy. CRT: chemoradiotherapy. MMC: Mitomycin C. Appendix D. Outcome definitions given in each study, stratified into nine categories. The final stratification yielded three disease activity outcome categories and six survival outcome categories. Appendix E. All outcomes reported in each study, along with all factors tested in both univariable and multivariable analysis. Appendix F. Clinical factors identified as prognostic for worse outcomes through univariable and multivariable analysis, stratified by outcome. Where available, factor effects and parameterisation used for analysis are also included. Appendix G. Biomarkers identified as prognostic for worse outcomes through univariable and multivariable analysis, stratified by outcome. Where available, factor effects and parameterisation used for analysis are also included. Appendix H. Imaging factors identified as prognostic for worse outcomes through univariable and multivariable analysis, stratified by outcome. Where available, factor effects are also included.