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Airborne mammary carcinogens and breast cancer risk in the Sister Study
- Source :
- Environ Int, Environment International, Vol 130, Iss, Pp-(2019)
- Publication Year :
- 2019
-
Abstract
- Introduction: Potentially carcinogenic hazardous air pollutants (air toxics) have been inconsistently associated with breast cancer. Whether metabolic factors modify these associations is unknown. We studied 29 non-metallic air toxics classified as mammary gland carcinogens in animal studies in relation to breast cancer risk. Methods: Participants included 49,718 women from the Sister Study. Census tract air toxic concentration estimates from the 2005 National Air Toxics Assessment were linked to enrollment residential addresses. Adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for individual air toxics were estimated using Cox regression. Body mass index (BMI) was considered a potential modifier. Relevant mixtures were identified using classification trees. Results: Over follow-up (average = 8.4 years), 2975 women were newly diagnosed with breast cancer (invasive or ductal carcinoma in situ). Several air toxics, including methylene chloride, polycyclic organic matter, propylene dichloride, and styrene, were associated with increased risk. Of these, methylene chloride was most consistently associated with risk across multiple analyses. It was associated with overall (HRquintile 4vs1 = 1.21 (95%CI = 1.07–1.38)) and estrogen receptor positive (ER+) invasive breast cancer (HRquintile 4vs1 = 1.28 (95%CI = 1.08–1.52)) in individual pollutant models, although no dose-response was observed. Associations were stronger among overweight/obese (vs. non-overweight/obese) women (p
- Subjects :
- Oncology
medicine.medical_specialty
010504 meteorology & atmospheric sciences
Mammary gland
Estrogen receptor
Breast Neoplasms
010501 environmental sciences
Overweight
01 natural sciences
Article
Cohort Studies
Breast cancer
Internal medicine
Air Pollution
medicine
Humans
lcsh:Environmental sciences
Carcinogen
0105 earth and related environmental sciences
General Environmental Science
lcsh:GE1-350
Air Pollutants
Proportional hazards model
business.industry
Hazard ratio
medicine.disease
medicine.anatomical_structure
Carcinogens
Female
medicine.symptom
business
Body mass index
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Environ Int, Environment International, Vol 130, Iss, Pp-(2019)
- Accession number :
- edsair.doi.dedup.....6796f8a03e368bd52f482b4554bf2dde