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Clinical and metabolic response to probiotic administration in people with Parkinson's disease: A randomized, double-blind, placebo-controlled trial
- Source :
- Clinical nutrition (Edinburgh, Scotland). 38(3)
- Publication Year :
- 2018
-
Abstract
- The investigation was done to assess the impacts of probiotic supplementation on movement and metabolic parameters in individuals with Parkinson's disease (PD).The study is randomized, double-blind, placebo-controlled clinical trial, which was done in sixty people with PD. Individuals were randomly divided into two groups in order to take either 8 × 10Compared with the placebo, consuming probiotic decreased MDS-UPDRS (-4.8 ± 12.5 vs. +3.8 ± 13.0, P = 0.01). Probiotic supplementation also reduced high-sensitivity C-reactive protein (-1.6 ± 2.5 vs. +0.1 ± 0.3 mg/L, P 0.001) and malondialdehyde (-0.2 ± 0.3 vs. +0.1 ± 0.3 μmol/L, P = 0.006), and enhanced glutathione levels (+40.1 ± 81.5 vs. -12.1 ± 41.7 μmol/L, P = 0.03) in comparison with the placebo. Additionally, probiotic consumption resulted in a statistically significant reduction in insulin levels (-2.1 ± 3.4 vs. +1.5 ± 5.1 μIU/mL, P = 0.002) and insulin resistance (-0.5 ± 0.9 vs. +0.4 ± 1.2, P = 0.002), and a statistically significant rise in insulin sensitivity (+0.01 ± 0.02 vs. -0.006 ± 0.02, P = 0.01) in comparison with the placebo. Probiotic intake had no any significant impact on other metabolic profiles.Our study evidenced that 12 weeks of probiotic consumption by individuals with PD had useful impacts on MDS-UPDRS and few metabolic profiles. Registered under ClinicalTrials.gov Identifier no. http://www.irct.ir: IRCT2017082434497N4.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Parkinson's disease
Movement disorders
Placebo-controlled study
030209 endocrinology & metabolism
Disease
Critical Care and Intensive Care Medicine
Placebo
law.invention
03 medical and health sciences
Probiotic
0302 clinical medicine
Double-Blind Method
law
Rating scale
Internal medicine
Medicine
Humans
Aged
Aged, 80 and over
030109 nutrition & dietetics
Nutrition and Dietetics
business.industry
Probiotics
Parkinson Disease
Middle Aged
medicine.disease
Clinical trial
Oxidative Stress
Cholesterol
medicine.symptom
business
Subjects
Details
- ISSN :
- 15321983
- Volume :
- 38
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Clinical nutrition (Edinburgh, Scotland)
- Accession number :
- edsair.doi.dedup.....6796308154983f9a0bcefc42551fd7d7