Back to Search
Start Over
The influence of roller compaction processing variables on the rheological properties of granules
- Source :
- Asian Journal of Pharmaceutical Sciences, Vol 11, Iss 4, Pp 516-527 (2016), Scopus-Elsevier
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- This study is part of an ongoing project to enable the full specification of the Design Space for roller compactor systems and shows how the processing parameters influence the behaviour of the product granulate from a placebo formulation. Granulate was produced using a proprietary roller compactor by varying the compaction pressure and gap width, and the dynamic, bulk and shear properties of the resultant granulates were measured. The results demonstrate several rheological properties of the granulate, which have been shown to be closely correlated with variance in die filling and tablet strength, and are predictably influenced by the processing parameters.
- Subjects :
- Pharmacology
Materials science
lcsh:RM1-950
Compaction
Pharmaceutical Science
02 engineering and technology
Roller compaction
021001 nanoscience & nanotechnology
Dry granulation
lcsh:Therapeutics. Pharmacology
020401 chemical engineering
Shear (geology)
Rheology
Gap width
Powder rheology
0204 chemical engineering
Composite material
0210 nano-technology
Design space
Subjects
Details
- ISSN :
- 18180876
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Asian Journal of Pharmaceutical Sciences
- Accession number :
- edsair.doi.dedup.....679116426ae4a3ea8fc9956b28b4bbde