An introduction to the neurobiology of oro-facial growth

Neurotrophism describes a non-membrane conductive activity by which interactions occur between neurons and other cells which initiate or control molecular modifications in other cells. Neuro-epithelial, neuro-muscular, and neuro-visceral trophism is defined and discussed in some detail. Some emphasis is given to data indicating possible neurotrophic control of genetic activity of muscle. It is considered that oro-facial growth may be conceived of as a homeostatically controlled series of processes in which the neural center regulates the peripheral tissues and the periphery, in turn, regulates the center. While this neurobiological hypothesis may stimulate future research, we must clearly understand that we must also inquire as to the means by which neurotrophism is integrated with those other processes involved in growth regulation.