IMPACT OF EXPERIMENTAL OBESITY ON DIAPHRAGM STRUCTURE, FUNCTION, AND BIOENERGETICS

Authors :: Juliana Woyames
Vera Luiza Capelozzi
Pedro L. Silva
Flavia Fonseca Bloise
Gisele C. Rodrigues
Nazareth N. Rocha
Wagner Seixas da Silva
Lígia de A. Maia
Patricia R. M. Rocco
Glenn Paul Abela
Mariana A. Antunes
Isabella Melo
Lorenzo Ball
Paolo Pelosi
Ana Carolina Quirino Simões
Publication Year :: 2020
Abstract: Obesity is associated with bioenergetic dysfunction of peripheral muscles; however, little is known regarding the impact of obesity on the diaphragm. We hypothesized that obesity would be associated with diaphragm dysfunction attributable to mitochondrial oxygen consumption and structural and ultrastructural changes. Wistar rat litters were culled to 3 pups to induce early postnatal overfeeding and consequent obesity. Control animals were obtained from unculled litters. From

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