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Sugar-Lowering Drugs for Type 2 Diabetes Mellitus and Metabolic Syndrome Strategies for In Vivo Administration: Part-II
- Source :
- Journal of Clinical Medicine, Vol 8, Iss 9, p 1332 (2019), Dipòsit Digital de la UB, Universidad de Barcelona, Journal of Clinical Medicine, Repositório Científico de Acesso Aberto de Portugal, Repositório Científico de Acesso Aberto de Portugal (RCAAP), instacron:RCAAP
- Publication Year :
- 2019
- Publisher :
- MDPI, 2019.
-
Abstract
- Diabetes is a complex disease characterized by hyperglycemia, together with polyuria, polydipsia, and polyphagia. While Type 1 diabetes mellitus (T1DM) results from genetic, environmental, or immune dysfunction factors leading to pancreatic ß-cell destruction depriving the organism from endogenous insulin, Type 2 diabetes mellitus (T2DM) is characterized by peripheral insulin resistance. Depending on the type of diabetes mellitus and drug mechanism to study, the animal model should be carefully selected among the wide variety of the currently available ones. This review discusses the most common animal models currently employed to study T1DM and T2DM. Moreover, an overview on the administration routes that could be used is also discussed.<br />The authors acknowledge the financial support received from Portuguese Science and TechnologyFoundation (FCT/MCT) and from European Funds (PRODER/COMPETE) under the project referenceM-ERA-NET/0004/2015-PAIRED, co-financed by FEDER, under the Partnership Agreement PT2020. The authors also acknowledge the support of the Institute of Nanoscience and Nanotechnology under the project ART (2018).<br />info:eu-repo/semantics/publishedVersion
- Subjects :
- Farmacologia
endocrine system diseases
medicine.medical_treatment
lcsh:Medicine
Review
Bioinformatics
Diabetis no-insulinodependent
03 medical and health sciences
0302 clinical medicine
Polyuria
Diabetes mellitus
medicine
Animals
Non-insulin-dependent diabetes
030304 developmental biology
Pharmacology
0303 health sciences
Type 1 diabetes
Science & Technology
administration route
diabetes mellitu
business.industry
animal model
Insulin
lcsh:R
Type 2 Diabetes Mellitus
nutritional and metabolic diseases
Insulin resistance
General Medicine
medicine.disease
administration routes
animal models
3. Good health
in vivo
Polyphagia
030220 oncology & carcinogenesis
diabetes mellitus
medicine.symptom
Metabolic syndrome
Resistència a la insulina
business
Polydipsia
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical Medicine, Vol 8, Iss 9, p 1332 (2019), Dipòsit Digital de la UB, Universidad de Barcelona, Journal of Clinical Medicine, Repositório Científico de Acesso Aberto de Portugal, Repositório Científico de Acesso Aberto de Portugal (RCAAP), instacron:RCAAP
- Accession number :
- edsair.doi.dedup.....676cb204b50c7af5955b33c2af341859