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Philosophical Basis and Some Historical Aspects of Systems Biology: From Hegel to Noble - Applications for Bioenergetic Research
- Source :
- International Journal of Molecular Sciences, Vol 10, Iss 3, Pp 1161-1192 (2009), International Journal of Molecular Sciences, International Journal of Molecular Sciences, MDPI, 2009, 10 (3), pp.1161-92. ⟨10.3390/ijms10031161⟩
- Publication Year :
- 2009
- Publisher :
- MDPI AG, 2009.
-
Abstract
- International audience; We live in times of paradigmatic changes for the biological sciences. Reductionism, that for the last six decades has been the philosophical basis of biochemistry and molecular biology, is being displaced by Systems Biology, which favors the study of integrated systems. Historically, Systems Biology - defined as the higher level analysis of complex biological systems - was pioneered by Claude Bernard in physiology, Norbert Wiener with the development of cybernetics, and Erwin Schrödinger in his thermodynamic approach to the living. Systems Biology applies methods inspired by cybernetics, network analysis, and non-equilibrium dynamics of open systems. These developments follow very precisely the dialectical principles of development from thesis to antithesis to synthesis discovered by Hegel. Systems Biology opens new perspectives for studies of the integrated processes of energy metabolism in different cells. These integrated systems acquire new, system-level properties due to interaction of cellular components, such as metabolic compartmentation, channeling and functional coupling mechanisms, which are central for regulation of the energy fluxes. State of the art of these studies in the new area of Molecular System Bioenergetics is analyzed.
- Subjects :
- Systems biology
Citric Acid Cycle
Energy metabolism
Molecular Systems Bioenergetics
Review
030204 cardiovascular system & hematology
Biology
History, 18th Century
Catalysis
Inorganic Chemistry
lcsh:Chemistry
03 medical and health sciences
Antithesis
0302 clinical medicine
Myofibrils
compartmentation
[SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology
Cybernetics
[SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology
Physical and Theoretical Chemistry
Molecular Biology
lcsh:QH301-705.5
Spectroscopy
030304 developmental biology
Cognitive science
Dialectic
0303 health sciences
Reductionism
Systems Biology
Organic Chemistry
Hegelianism
History, 19th Century
regulation
General Medicine
Models, Theoretical
Computer Science Applications
Mitochondria
cellular energy metabolism
Energy (psychological)
energy transfer systems
lcsh:Biology (General)
lcsh:QD1-999
Biophysics
Energy Metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 14220067 and 16616596
- Volume :
- 10
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences
- Accession number :
- edsair.doi.dedup.....676093ed7ed57091de762843ac887c36