Sensitivity of Trypanosoma equiperdum to the action of tumor-inhibitory antibiotics in vivo

THE marked sensitivity in vitro1 of various metabolic pathways in T. equiperdum to actinomycin D, mitomycin C, porfiromycin, phleomycin, and pactamycin indicated that these tumour-inhibitory antibiotics may be trypanocidal in vivo. Our results show this to be so with all except pactamycin, and also that phleomycin and porfiromycin in particular cured a high percentage of infected mice at certain dosages.