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The Obesity Risk SNP (rs17782313) near the MC4R Gene Is Not Associated with Brain Glucose Uptake during Insulin Clamp—A Study in Finns
- Source :
- Journal of Clinical Medicine, Volume 10, Issue 6, Journal of Clinical Medicine, Vol 10, Iss 1312, p 1312 (2021)
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- The melanocortin system is involved in the control of adiposity through modulation of food intake and energy expenditure. The single nucleotide polymorphism (SNP) rs17782313 near the MC4R gene has been linked to obesity, and a previous study using magnetoencephalography has shown that carriers of the mutant allele have decreased cerebrocortical response to insulin. Thus, in this study, we addressed whether rs17782313 associates with brain glucose uptake (BGU). Here, [18F]-fluorodeoxyglucose positron emission tomography (PET) data from 113 Finnish subjects scanned under insulin clamp conditions who also had the rs17782313 determined were compiled from a single-center cohort. BGU was quantified by the fractional uptake rate. Statistical analysis was performed with statistical parametric mapping. There was no difference in age, BMI, and insulin sensitivity as indexed by the M value between the rs17782313-C allele carriers and non-carriers. Brain glucose uptake during insulin clamp was not different by gene allele, and it correlated with the M value, in both the rs17782313-C allele carriers and non-carriers. The obesity risk SNP rs17782313 near the MC4R gene is not associated with brain glucose uptake during insulin clamp in humans, and this frequent mutation cannot explain the enhanced brain glucose metabolic rates in insulin resistance.
- Subjects :
- medicine.medical_specialty
positron emission tomography
Glucose uptake
medicine.medical_treatment
lcsh:Medicine
030209 endocrinology & metabolism
Single-nucleotide polymorphism
Article
03 medical and health sciences
0302 clinical medicine
Insulin resistance
single nucleotide polymorphism
insulin resistance
Internal medicine
medicine
SNP
brain glucose uptake
Allele
030304 developmental biology
2. Zero hunger
0303 health sciences
business.industry
Insulin
lcsh:R
General Medicine
medicine.disease
Obesity
rs17782313
Endocrinology
Melanocortin
business
Subjects
Details
- ISSN :
- 20770383
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical Medicine
- Accession number :
- edsair.doi.dedup.....675b09fae82265a96d4c13054f76e74a