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Effect of purine nucleosides on growth performance, gut morphology, digestive enzymes, serum profile and immune response in broiler chickens
- Source :
- British Poultry Science. 58:536-543
- Publication Year :
- 2017
- Publisher :
- Informa UK Limited, 2017.
-
Abstract
- 1. This study was conducted to evaluate the effects of purine nucleosides on performance, gut morphology, intestinal enzymes and immunity functions in broiler chickens from 0 to 21 d of age. 2. A total of 360 1-d-old male chickens (Cobb 500) were randomly assigned to 4 treatments with 6 replications. Experimental diets consisted of a control without any additives and diets containing 0.1% pure adenosine, 0.1% pure guanosine and 0.1% equal aliquots of pure adenosine and guanosine. Two birds per cage (12 birds per treatment) were killed on d 11 and 21 in order to obtain serum samples for lipid profile, jejunal samples for morphology and mucosal immunity, digestive enzymes for epithelial maturation, and bursa and spleen samples for relative weight of immune organs to live body weight. 3. Birds receiving adenosine in their diets showed a significant increase in body weight and average daily gain and a significantly lower feed conversion ratio compared to the control birds. Villus height and width in jejunal samples also increased significantly in birds supplemented with adenosine. Although maltase was not affected by the experimental diets, adenosine increased alkaline phosphatase and aminopeptidase. Adenosine and its combination with guanosine boosted mucosal immunity as a result of increased IgA production. While there was no significant difference among treatments regarding the relative weight of the spleen, adenosine increased the relative weight of the bursa of Fabricius. Present results also showed that adding guanosine to broiler diets had no significant effects on growth, gut morphology, enzymes activity and immunological indices. 4. In conclusion, the improvement in growth performance, gut morphology and immunity in birds receiving adenosine demonstrated that pure adenosine could be a beneficial feed additive for the poultry industry, while guanosine showed no significant improvement.
- Subjects :
- Male
0301 basic medicine
Purine
animal structures
animal diseases
Biology
digestive system
Random Allocation
03 medical and health sciences
chemistry.chemical_compound
Bursa of Fabricius
Immune system
Immunity
Animals
Intestinal Mucosa
Immunity, Mucosal
chemistry.chemical_classification
030109 nutrition & dietetics
Intestinal enzymes
Gut morphology
digestive, oral, and skin physiology
0402 animal and dairy science
Broiler
Organ Size
Purine Nucleosides
04 agricultural and veterinary sciences
General Medicine
Animal Feed
040201 dairy & animal science
Diet
Intestines
Enzyme
chemistry
Biochemistry
Dietary Supplements
Animal Nutritional Physiological Phenomena
Animal Science and Zoology
Chickens
Spleen
Food Science
Subjects
Details
- ISSN :
- 14661799 and 00071668
- Volume :
- 58
- Database :
- OpenAIRE
- Journal :
- British Poultry Science
- Accession number :
- edsair.doi.dedup.....67588c0547b1421447af5abe4a64294f