Back to Search
Start Over
Towards a consistent definition of a significant delta troponin with z-scores: a way out of chaos?
- Source :
- European Heart Journal: Acute Cardiovascular Care. 3:149-157
- Publication Year :
- 2013
- Publisher :
- Oxford University Press (OUP), 2013.
-
Abstract
- Aims: We assessed the diagnostic performance of z-scores to define a significant delta cardiac troponin (cTn) in a cohort of patients with well-defined clinical outcomes. Methods: We calculated z-scores, which are dependent on the analytical precision and biological variation, to report changes in cTn. We compared the diagnostic performances of a relative delta (%Δ), actual delta (Δ), and z-scores in 762 emergency department patients with symptoms of suspected acute coronary syndrome. cTn was measured with sensitive cTnI (Beckman Coulter), highly sensitive cTnI (Abbott), and highly sensitive cTnT (Roche) assays. Results: Receiver operating characteristic analysis showed no statistically significant differences in the areas under the curve (AUC) of z-scores and Δ with both superior compared to %Δ for all three assays (p
- Subjects :
- Adult
Male
medicine.medical_specialty
Pathology
Cardiac troponin
Myocardial Infarction
Standard score
Critical Care and Intensive Care Medicine
Cohort Studies
Troponin complex
Biological variation
Internal medicine
Troponin I
Humans
Medicine
Acute Coronary Syndrome
Aged
Aged, 80 and over
biology
Receiver operating characteristic analysis
business.industry
General Medicine
Middle Aged
Reference Standards
Troponin
Highly sensitive
ROC Curve
biology.protein
Cardiology
Female
Cardiology and Cardiovascular Medicine
business
Biomarkers
Subjects
Details
- ISSN :
- 20488734 and 20488726
- Volume :
- 3
- Database :
- OpenAIRE
- Journal :
- European Heart Journal: Acute Cardiovascular Care
- Accession number :
- edsair.doi.dedup.....674c3dfc3878ed5c8c34def493d71ad8