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Micronutrient deficits in patients with chronic pancreatitis: prevalence, risk factors and pitfalls
- Source :
- Jøker-Jensen, H, Mathiasen, A S, Køhler, M, Rasmussen, H H, Drewes, A M & Olesen, S S 2020, ' Micronutrient deficits in patients with chronic pancreatitis : prevalence, risk factors and pitfalls ', European Journal of Gastroenterology and Hepatology, vol. 32, no. 10, pp. 1328-1334 . https://doi.org/10.1097/MEG.0000000000001866
- Publication Year :
- 2020
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2020.
-
Abstract
- OBJECTIVE: We investigated the prevalence of micronutrient deficiencies and associated patient and disease-related risk factors in patients with chronic pancreatitis (CP).METHODS: We enrolled 115 consecutive CP outpatients. Micro-nutritional assessments included plasma levels of fat-soluble vitamins (A, D and E) and trace elements (magnesium and zinc). Bioelectrical impedance and muscle function tests were used to characterize the macro-nutritional status (sarcopenia and phase angle). Prevalence of micro-nutritional deficiencies was estimated and associated with a number of patient and disease characteristics including presence of exocrine pancreatic insufficiency (EPI) and diabetes mellitus. In an additional analysis, we explored the association between micronutrient levels and macro-nutritional status.RESULTS: The mean age of patients was 57.9 ± 13.0 years, 71% were men and 50% had an alcoholic aetiology. Vitamin D deficiency (22%) was the most common micronutrient deficit followed by zinc deficiency (20%) and magnesium deficiency (17%). Vitamin A deficiency (10%) and vitamin E deficiency (7%) were only seen in patients with EPI (P ≤ 0.03), while the presence of trace element deficits was associated with plasma albumin levels (P ≤ 0.006). Plasma zinc levels were decreased in sarcopenic patients (P < 0.001) and positively correlated to phase angle (coefficient 0.28; P < 0.001).CONCLUSION: Various micronutrient deficits were observed in CP outpatients, and associated risk factors were diverse and distinct for the individual nutrients. Taken together, our findings highlight the complexity of micronutrient assessment in patients with CP and emphasise the importance of simultaneous evaluation of plasma protein levels, inflammatory activity and macro-nutritional status.
- Subjects :
- Adult
Male
medicine.medical_specialty
Nutritional Status
Gastroenterology
vitamin D deficiency
chronic pancreatitis
sarcopenia
BMI
03 medical and health sciences
0302 clinical medicine
Risk Factors
Pancreatitis, Chronic
Zinc deficiency (plant disorder)
Magnesium deficiency (medicine)
Internal medicine
Prevalence
medicine
Humans
Micronutrients
Exocrine pancreatic insufficiency
albumin
Aged
Hepatology
business.industry
Middle Aged
medicine.disease
Micronutrient
exocrine pancreatic insufficiency
phase angle
Trace Elements
Vitamin A deficiency
micronutrients
030220 oncology & carcinogenesis
Sarcopenia
030211 gastroenterology & hepatology
Vitamin E deficiency
business
Subjects
Details
- ISSN :
- 0954691X
- Volume :
- 32
- Database :
- OpenAIRE
- Journal :
- European Journal of Gastroenterology & Hepatology
- Accession number :
- edsair.doi.dedup.....6740006c546d8b0729016bd02a32043d