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The feasibility and acceptability of research magnetic resonance imaging in adolescents with moderate–severe neuropathic pain
- Source :
- Pain Reports
- Publication Year :
- 2020
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2020.
-
Abstract
- Supplemental Digital Content is Available in the Text.<br />Introduction: Multimodal characterisation with questionnaires, Quantitative Sensory Testing (QST), and neuroimaging will improve understanding of neuropathic pain (NeuP) in adolescents. Magnetic resonance imaging (MRI) data in adolescents with NeuP are limited, and the perceived practical or ethical burden of scanning may represent a barrier to research. Objective: To determine the feasibility of MRI scanning in adolescents with moderate–severe NeuP, with respect to consent rate, postscan acceptability, and data quality. Methods: This prospective cohort study evaluating questionnaires and QST recruited adolescents aged 10 to 18 years with clinically diagnosed NeuP from a tertiary clinic. Eligible adolescents aged 11 years and older could additionally agree/decline an MRI scan. After the scan, families rated discomfort, perceived risk, and acceptability of current and future MRI scans (0–10 numerical rating scales). Head motion during scanning was compared with healthy controls to assess data quality. Results: Thirty-four families agreed to MRI (72% recruitment), and 21 adolescents with moderate–severe pain (average last week 6.7 ± 1.7; mean ± SD) and with neuropathic QST profiles were scanned. Three adolescents reported positional or noise-related discomfort during scanning. Perceived risk was low, and acceptability of the current scan was high for parents (range [median]: 7 to 10/10 [10]) and adolescents (8–10/10 [10]). Willingness to undergo a future research scan was high for parents (7–10/10 [10]) and adolescents (5–10/10 [10]) and did not differ from future scans for clinical purposes. Mean head motion during resting state functional MRI did not differ from control adolescents. Conclusion: Research MRI is feasible and acceptable for many adolescents with moderate–severe NeuP.
- Subjects :
- medicine.medical_specialty
Pain
02 engineering and technology
Neuropathic pain
Adolescents
01 natural sciences
Magnetic resonance imaging
Neuroimaging
Rating scale
0103 physical sciences
0202 electrical engineering, electronic engineering, information engineering
Medicine
010306 general physics
Prospective cohort study
Mri scan
Children
Pediatric
medicine.diagnostic_test
business.industry
Quantitative sensory testing
Consent rate
Anesthesiology and Pain Medicine
ComputingMethodologies_DOCUMENTANDTEXTPROCESSING
Physical therapy
020201 artificial intelligence & image processing
business
Research Paper
Subjects
Details
- ISSN :
- 24712531
- Volume :
- 5
- Database :
- OpenAIRE
- Journal :
- PAIN Reports
- Accession number :
- edsair.doi.dedup.....67358ff063cfd2ce86058927180b4c55