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Empirical support for the vascular apathy hypothesis: A structured review
- Source :
- International Journal of Geriatric Psychiatry, Wouts, L, van Kessel, M, Beekman, A T F, Marijnissen, R M & Oude Voshaar, R C 2020, ' Empirical support for the vascular apathy hypothesis : A structured review ', International Journal of Geriatric Psychiatry, vol. 35, no. 1, pp. 3-11 . https://doi.org/10.1002/gps.5217
- Publication Year :
- 2019
- Publisher :
- Wiley, 2019.
-
Abstract
- Objectives: A systematic review of the relationship between subclinical small vessel disease (SSVD) in the general population and apathy to examine the hypothesis that apathy has a vascular basis. Methods: We searched for studies on associations between apathy and SSVD, operationalized as white matter hyperintensities (WMH) or white matter diffusivity changes, lacunar infarcts, cerebral microbleeds, decreasing cortical thickness, and perivascular spaces, while also peripheral proxies for SSVD were considered, operationalized as ankle brachial pressure index (ABI), intima media thickness, arterial stiffness, cardio-femoral pulse wave velocity, hypertension, or cardiovascular disease. Only eligible retrospective and prospective observational studies conducted in the general population were included. Results: The 14 studies eligible for review examined the associations between apathy and hypertension (3), ABI (1), arterial stiffness (1), cardiovascular disease (2), WMH (3), white matter diffusivity (2), cerebral microbleeds (1), or cortical thickness (3). Arterial stiffness and white matter diffusivity were not related to apathy, while the associations with cortical thickness were contradictory. Cross-sectional studies in the general population did find evidence of apathy being associated with WMH, CM, cardiovascular disease, hypertension, and ABI, and cardiovascular disease was prospectively associated with apathy. The methodologies of the studies reviewed were too heterogeneous to perform meta-analyses. Conclusions: Although more prospective evidence is needed and vascular depression needs to be controlled for, cardiovascular disease, hypertension, and ABI as proxies for SSVD, and WMH and cerebral microbleeds as direct measures of SSVD have been found to be associated with apathy in the general population, supporting the hypothesis of vascular apathy.
- Subjects :
- MILD COGNITIVE IMPAIRMENT
vascular apathy
medicine.medical_specialty
SYMPTOMS
small vessel disease
DIAGNOSTIC-CRITERIA
Apathy
Population
BLOOD-PRESSURE
Review Article
Empirical Research
White matter
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Humans
Prospective Studies
Vascular Diseases
education
Review Articles
Pulse wave velocity
Depression (differential diagnoses)
Retrospective Studies
INCIDENT CARDIOVASCULAR-DISEASE
education.field_of_study
030214 geriatrics
business.industry
DEPRESSION HYPOTHESIS
OLDER PERSONS
medicine.disease
Hyperintensity
cerebrovascular disease
ALZHEIMERS-DISEASE
COMMUNITY
Observational Studies as Topic
Psychiatry and Mental health
medicine.anatomical_structure
Intima-media thickness
Arterial stiffness
Cardiology
Geriatrics and Gerontology
medicine.symptom
business
Subjects
Details
- ISSN :
- 10991166 and 08856230
- Volume :
- 35
- Database :
- OpenAIRE
- Journal :
- International Journal of Geriatric Psychiatry
- Accession number :
- edsair.doi.dedup.....6734b095ee87169a593ba0c269dd58fc