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Microdosimetry model for boron neutron capture therapy: II. Theoretical estimation of the effectiveness function and surviving fractions
- Source :
- Radiation research. 155(3)
- Publication Year :
- 2001
-
Abstract
- A model has been developed to obtain a better understanding of the effects of boron neutron capture therapy (BNCT) on a cellular scale. This model, the microdosimetry model MICOR, has been developed to include all reactions important for BNCT. To make the model more powerful in the translation from energy deposition to biological effect, it has been designed to be capable of calculating the effectiveness function. Based on this function, the model can calculate surviving fractions, RBE values and boron concentration distributions. MICOR has been used to analyze an extensive set of biological experiments performed at the HB11 beam in Petten. For V79 Chinese hamster cells, the effectiveness function is determined and used to generate surviving fractions. These fractions are compared with measured surviving fractions, which results in a good agreement between the measured and calculated surviving fractions (within the uncertainties of the measurements).
- Subjects :
- Radiation
Energy distribution
Scale (ratio)
business.industry
Cell Survival
Biophysics
chemistry.chemical_element
Boron Neutron Capture Therapy
Function (mathematics)
Biological effect
Radiation Dosage
Models, Biological
Cell Line
Neutron capture
Boron concentration
chemistry
Cricetinae
Dosimetry
Animals
Radiology, Nuclear Medicine and imaging
Biological system
Nuclear medicine
business
Boron
Subjects
Details
- ISSN :
- 00337587
- Volume :
- 155
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Radiation research
- Accession number :
- edsair.doi.dedup.....67295b1375858753b4d9259692046420