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Biological effects of metal degradation in hip arthroplasties
Biological effects of metal degradation in hip arthroplasties
- Source :
- Critical reviews in toxicology. 48(2)
- Publication Year :
- 2017
-
Abstract
- Metals and metal alloys are the most used materials in orthopedic implants. The focus is on total hip arthroplasty (THA) that, though well tolerated, may be associated with local and remote adverse effects in the medium-long term. This review aims to summarize data on the biological consequences of the metal implant degradation that have been attributed predominantly to metal-on-metal (MoM) THA. Local responses to metals consist of a broad clinical spectrum ranging from small asymptomatic tissue lesions to severe destruction of bone and soft tissues, which are designated as metallosis, adverse reactions to metal debris (ARMD), aseptic lymphocytic vasculitis associated lesion (ALVAL), and pseudotumors. In addition, the dissemination of metal particles and ions throughout the body has been associated with systemic adverse effects, including organ toxicity, cancerogenesis, teratogenicity, and immunotoxicity. As proved by the multitude of studies in this field, metal degradation may increase safety issues associated with THA, especially with MoM hip systems. Data collection regarding local, systemic and long-term effects plays an essential role to better define any safety risks and to generate scientifically based recommendations.
- Subjects :
- wear
medicine.medical_specialty
Arthroplasty, Replacement, Hip
Metal toxicity
Toxicology
local adverse effect
03 medical and health sciences
0302 clinical medicine
medicine
Immune Tolerance
Metallosis
Humans
systemic adverse effect
Adverse effect
030222 orthopedics
corrosion
metal toxicity
business.industry
Metal implant
Soft tissue
Metal debris
medicine.disease
Surgery
Metals
030220 oncology & carcinogenesis
Orthopedic surgery
Practice Guidelines as Topic
Total joint arthroplasty
Metal-on-Metal Joint Prostheses
Hip Prosthesis
business
Total hip arthroplasty
Subjects
Details
- ISSN :
- 15476898
- Volume :
- 48
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Critical reviews in toxicology
- Accession number :
- edsair.doi.dedup.....6725e932205500a41abf74b20b50ec93