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Incidence, prevalence, mortality and chronic renal damage of anti-neutrophil cytoplasmic antibody–associated glomerulonephritis in a 20-year population-based cohort
- Source :
- Nephrology Dialysis Transplantation, Nephrology Dialysis Transplantation, Oxford University Press (OUP), 2018, ⟨10.1093/ndt/gfy250⟩
- Publication Year :
- 2018
- Publisher :
- HAL CCSD, 2018.
-
Abstract
- Background True population-based clinical and outcomes data are lacking for anti-neutrophil cytoplasmic autoantibody (ANCA)-associated glomerulonephritis (AAGN). Therefore we aimed to estimate the incidence, prevalence and mortality of AAGN, as well as the relationship between the grade of chronic renal damage at presentation and renal and non-renal outcomes. Methods Patients with AAGN were identified among a population-based incident cohort of 57 Olmsted County residents diagnosed with ANCA-associated vasculitis (AAV) in 1996–2015. Incidence rates were age and sex adjusted to the 2010 US white population. Age- and sex-adjusted prevalence was calculated for 1 January 2015. Survival rates were compared with expected rates in the Minnesota population. Chronic renal damage was assessed by chronicity score (CS) on biopsies performed at diagnosis. Results Thirty-four (60%) patients had AAGN. Of these, 65% had microscopic polyangiitis (MPA) and 74% were myeloperoxidase (MPO)-ANCA positive. The annual incidence of AAGN was 2.0/100 000 population [95% confidence interval (CI) 1.3–2.7] and the overall prevalence was 35/100 000 (95% CI 24–47). Mortality for AAGN was increased (P Conclusions The annual incidence and prevalence of AAGN in Minnesota are 2.0/100 000 and 35/100 000, respectively. Mortality is worse compared with AAV patients without glomerulonephritis. More advanced renal damage at diagnosis predicts less renal recovery.
- Subjects :
- Male
medicine.medical_specialty
Minnesota
Myeloblastin
[SDV]Life Sciences [q-bio]
Population
030232 urology & nephrology
Renal function
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
030204 cardiovascular system & hematology
urologic and male genital diseases
Gastroenterology
Antibodies, Antineutrophil Cytoplasmic
Cohort Studies
03 medical and health sciences
0302 clinical medicine
Glomerulonephritis
Internal medicine
Prevalence
Medicine
Humans
education
Anti-neutrophil cytoplasmic antibody
Aged
Peroxidase
Transplantation
Kidney
education.field_of_study
business.industry
Incidence (epidemiology)
Incidence
Middle Aged
medicine.disease
Prognosis
3. Good health
Survival Rate
medicine.anatomical_structure
Nephrology
Cohort
Female
business
Granulomatosis with polyangiitis
Microscopic polyangiitis
Subjects
Details
- Language :
- English
- ISSN :
- 09310509 and 14602385
- Database :
- OpenAIRE
- Journal :
- Nephrology Dialysis Transplantation, Nephrology Dialysis Transplantation, Oxford University Press (OUP), 2018, ⟨10.1093/ndt/gfy250⟩
- Accession number :
- edsair.doi.dedup.....67252b98fc9b98281870424900f81078