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Hypertrophic Scar Outcomes in Fractional Laser Monotherapy Versus Fractional Laser-Assisted Topical Corticosteroid Delivery: A Randomized Clinical Trial
- Source :
- Acta Dermato-Venereologica, Vol 101, Iss 3, p adv00416 (2021)
- Publication Year :
- 2021
- Publisher :
- Medical Journals Sweden AB, 2021.
-
Abstract
- Topical corticosteroid delivery following fractional laser treatment is an effective means of treating hypertrophic scars. However, the relative efficacy of adjuvant corticosteroid treatment vs fractional laser mono-therapy alone is unclear. The aim of this study was to compare the efficacy and safety of fractional laser-assisted topical corticosteroid delivery with fractional laser monotherapy in the treatment of hyper-trophic scars. In this randomized, comparative, split-scar trial of 19 subjects, a borderline significant reduction in scar thickness was observed at 3-month follow-up in the laser+steroid group compared with laser+petrolatum (p = 0.049). However, no significant long-term difference in scar flattening was observed between the 2 groups. Patient and Observer Scar Assessment Scale scores showed significant improvement in scar appearance from baseline without significant differences between treatment groups. In conclusion, fractional laser monotherapy is an effective treatment for hypertrophic scars, and the application of topical corticosteroid provides no long-term synergistic effect to fractional laser monotherapy.
- Subjects :
- corticosteroid
medicine.medical_specialty
Cicatrix, Hypertrophic
medicine.drug_class
medicine.medical_treatment
Fractional laser
laser-assisted drug delivery
Urology
Scars
Dermatology
law.invention
Hypertrophic scar
Randomized controlled trial
law
Humans
Medicine
Effective treatment
Low-Level Light Therapy
business.industry
hypertrophic scar
General Medicine
medicine.disease
Treatment Outcome
Topical corticosteroid
RL1-803
Lasers, Gas
Corticosteroid
fractional laser
Laser Therapy
medicine.symptom
business
Adjuvant
Subjects
Details
- ISSN :
- 16512057
- Volume :
- 101
- Database :
- OpenAIRE
- Journal :
- Acta Dermato Venereologica
- Accession number :
- edsair.doi.dedup.....672361563fbc248042f5529a5c614639