Back to Search
Start Over
Differentially Abundant Bacterial Taxa Associated with Prognostic Variables of Crohn's Disease: Results from the IMPACT Study
- Source :
- Journal of Clinical Medicine, Vol 9, Iss 1748, p 1748 (2020), Journal of Clinical Medicine, Volume 9, Issue 6
- Publication Year :
- 2020
- Publisher :
- MDPI AG, 2020.
-
Abstract
- Limited studies have examined the intestinal microbiota composition in relation to Crohn&rsquo<br />s disease (CD) prognosis. We analyzed the differences in microbial communities and relevant metabolic pathways associated with prognostic variables in patients with CD. We applied 16S rRNA gene sequencing to analyze a cohort of 1110 CD and healthy control (HC) fecal samples. We categorized patients with CD into good (CD-G), intermediate (CD-I) and poor (CD-P) prognosis groups, according to the history of using biologics and intestinal resection. Microbiota &alpha<br />diversity decreased more in CD-P than CD-G and CD-I. Microbiota &szlig<br />diversity in CD-P differed from that in CD-G and CD-I. Thirteen genera and 10 species showed differential abundance between CD-G and CD-P groups. Escherichia coli (p = 0.001) and species Producta (p = 0.01) and genera Lactobacillus (p = 0.003) and Coprococcus (p = 0.01) consistently showed differences between CD-G and CD-P groups after adjusting for confounding variables. Functional profiling suggested that the microbial catabolic pathways and pathways related to enterobacterial common antigen and lipopolysaccharide biosynthesis were better represented in the CD-P group than in the CD-G group, and E. coli were the top contributors to these pathways. CD prognosis is associated with altered microbiota composition and decreased diversity, and E. coli might be causally involved in CD progression, and may have adapted to live in inflammatory environments.
- Subjects :
- Crohn’s disease
Prognostic variable
food.ingredient
lcsh:Medicine
Disease
medicine.disease_cause
digestive system
Article
Coprococcus
03 medical and health sciences
fluids and secretions
0302 clinical medicine
food
Lactobacillus
medicine
microbiota
Escherichia coli
Feces
030304 developmental biology
0303 health sciences
Crohn's disease
biology
business.industry
Confounding
lcsh:R
General Medicine
biology.organism_classification
medicine.disease
digestive system diseases
stomatognathic diseases
Immunology
030211 gastroenterology & hepatology
prognosis
business
Subjects
Details
- Language :
- English
- ISSN :
- 20770383
- Volume :
- 9
- Issue :
- 1748
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical Medicine
- Accession number :
- edsair.doi.dedup.....670cba8de3a3cf6d23a95277c98545cf