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The Post-genomic Era of Trichoderma reesei: What's Next?
- Source :
- Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual), Universidade de São Paulo (USP), instacron:USP
- Publication Year :
- 2016
-
Abstract
- The ascomycete Trichoderma reesei is one of the most well studied cellulolytic microorganisms. This fungus is widely used in the biotechnology industry, mainly in the production of biofuels. Due to its importance, its genome was sequenced in 2008, opening new avenues to study this microorganism. In this 'post-genomic' era, a transcriptomic and proteomic era has emerged. Here, we present an overview of new findings in the gene expression regulation network of T. reesei. We also discuss new rational strategies to obtain mutants that produce hydrolytic enzymes with a higher yield, using metabolic engineering. Finally, we present how synthetic biology strategies can be used to create engineered promoters to efficiently synthesize enzymes for biomass degradation to produce bioethanol.
- Subjects :
- 0301 basic medicine
Proteome
MICRORGANISMOS CELULOLĂTICOS
030106 microbiology
Bioengineering
Cellulase
Genome
Metabolic engineering
03 medical and health sciences
Synthetic biology
Gene Expression Regulation, Fungal
Trichoderma reesei
Regulation of gene expression
Trichoderma
biology
Ethanol
business.industry
food and beverages
Computational Biology
biology.organism_classification
Biotechnology
Metabolic Engineering
Biofuels
biology.protein
Genome, Fungal
business
Transcriptome
Subjects
Details
- ISSN :
- 18793096
- Volume :
- 34
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- Trends in biotechnology
- Accession number :
- edsair.doi.dedup.....670a0b45972fab23372b6acf7b803aaf