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The effect of heart failure and left ventricular assist device treatment on right ventricular mechanics: a computational study
- Source :
- BioMedical Engineering, BioMedical Engineering OnLine, Vol 17, Iss 1, Pp 1-13 (2018)
- Publication Year :
- 2017
-
Abstract
- Background and aims Although it is important to analyze the hemodynamic factors related to the right ventricle (RV) after left ventricular assist device (LVAD) implantation, previous studies have focused only on the alteration of the ventricular shape and lack quantitative analysis of the various hemodynamic parameters. Therefore, we quantitatively analyzed various hemodynamic parameters related to the RV under normal, heart failure (HF), and HF incorporated with continuous flow LVAD therapy by using a computational model. Methods In this study, we combined a three-dimensional finite element electromechanical model of ventricles, which is based on human ventricular morphology captured by magnetic resonance imaging (MRI) with a lumped model of the circulatory system and continuous flow LVAD function in order to construct an integrated model of an LVAD implanted-cardiovascular system. To induce systolic dysfunction, the magnitude of the calcium transient function under HF condition was reduced to 70% of the normal value, and the time constant was reduced by 30% of the normal value. Results Under the HF condition, the left ventricular end systolic pressure decreased, the left ventricular end diastolic pressure increased, and the pressure in the right atrium (RA), RV, and pulmonary artery (PA) increased compared with the normal condition. The LVAD therapy decreased the end-systolic pressure of the LV by 41%, RA by 29%, RV by 53%, and PA by 71%, but increased the right ventricular ejection fraction by 52% and cardiac output by 40%, while the stroke work was reduced by 67% compared with the HF condition without LVAD. The end-systolic ventricular tension and strain decreased with the LVAD treatment. Conclusion LVAD enhances CO and mechanical unloading of the LV as well as those of the RV and prevents pulmonary hypertension which can be induced by HF.
- Subjects :
- Cardiac output
medicine.medical_specialty
lcsh:Medical technology
medicine.medical_treatment
0206 medical engineering
Finite Element Analysis
Biomedical Engineering
Hemodynamics
Left ventricular assist device
02 engineering and technology
030204 cardiovascular system & hematology
Biomaterials
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine.artery
medicine
Humans
Radiology, Nuclear Medicine and imaging
Computer Simulation
Mechanical Phenomena
Heart Failure
Radiological and Ultrasound Technology
business.industry
Research
General Medicine
medicine.disease
equipment and supplies
020601 biomedical engineering
Biomechanical Phenomena
medicine.anatomical_structure
lcsh:R855-855.5
Electromechanical model
Ventricle
Heart failure
Ventricular assist device
Circulatory system
Pulmonary artery
Cardiology
Ventricular pressure
Ventricular Function, Right
Right ventricle
Heart-Assist Devices
business
Subjects
Details
- ISSN :
- 1475925X
- Volume :
- 17
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Biomedical engineering online
- Accession number :
- edsair.doi.dedup.....67074bcd9f4d81d3127d7cb85b665abc