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Multiresidue method for simultaneous analysis of aflatoxin M1, avermectins, organophosphate pesticides and milbemycin in milk by ultra-performance liquid chromatography coupled to tandem mass spectrometry
- Source :
- Food additivescontaminants. Part A, Chemistry, analysis, control, exposurerisk assessment. 33(6)
- Publication Year :
- 2016
-
Abstract
- A method developed for the simultaneous analysis of aflatoxin M1, abamectin, doramectin, eprinomectin, ivermectin, moxidectin, acephate, azinphos-ethyl, azinphos-methyl, diazinon, methamidophos, methidathion, mevinphos, pirimiphos-ethyl and pirimiphos-methyl in whole raw milk, based on the QuEChERS method for extraction and clean-up, with detection and quantification by ultra-performance liquid chromatography coupled to tandem mass spectrometry (UPLC-MS/MS) is described. The method was validated according to parameters of the Analytical Quality Assurance Manual from the Brazilian Ministry of Agriculture and Commission Decision 2002/657/EC, and proved suitable for analysis of these analytes within the proposed working range, with recovery values between 77% and 110%, a standard deviation lower than 20%, limits of detection between 0.05 and 0.99 µg l(-)(1), and limits of quantification between 0.15 and 1.98 µg l(-1). Samples from animals treated with abamectin, doramectin, ivermectin and diazinon were analysed by the validated method. Residues of aflatoxin M1 were also found in field samples at levels below the established maximum residue limit.
- Subjects :
- Aflatoxin
Diazinon
Health, Toxicology and Mutagenesis
Food Contamination
Methidathion
Toxicology
Quechers
01 natural sciences
chemistry.chemical_compound
0404 agricultural biotechnology
Tandem Mass Spectrometry
medicine
Animals
Doramectin
Chromatography, High Pressure Liquid
Detection limit
Chromatography
Ivermectin
Methamidophos
010401 analytical chemistry
Public Health, Environmental and Occupational Health
Pesticide Residues
Reproducibility of Results
04 agricultural and veterinary sciences
General Chemistry
General Medicine
040401 food science
Organophosphates
0104 chemical sciences
Milk
chemistry
Abamectin
Aflatoxin M1
Macrolides
Brazil
Food Science
medicine.drug
Subjects
Details
- ISSN :
- 19440057
- Volume :
- 33
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Food additivescontaminants. Part A, Chemistry, analysis, control, exposurerisk assessment
- Accession number :
- edsair.doi.dedup.....66f049a86aa926c6588b388703b4be2b