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DNA methylation markers in the diagnosis and prognosis of common leukemias
- Source :
- Signal Transduction and Targeted Therapy, Signal Transduction and Targeted Therapy, Vol 5, Iss 1, Pp 1-10 (2020)
- Publication Year :
- 2020
- Publisher :
- Springer Science and Business Media LLC, 2020.
-
Abstract
- The ability to identify a specific type of leukemia using minimally invasive biopsies holds great promise to improve the diagnosis, treatment selection, and prognosis prediction of patients. Using genome-wide methylation profiling and machine learning methods, we investigated the utility of CpG methylation status to differentiate blood from patients with acute lymphocytic leukemia (ALL) or acute myelogenous leukemia (AML) from normal blood. We established a CpG methylation panel that can distinguish ALL and AML blood from normal blood as well as ALL blood from AML blood with high sensitivity and specificity. We then developed a methylation-based survival classifier with 23 CpGs for ALL and 20 CpGs for AML that could successfully divide patients into high-risk and low-risk groups, with significant differences in clinical outcome in each leukemia type. Together, these findings demonstrate that methylation profiles can be highly sensitive and specific in the accurate diagnosis of ALL and AML, with implications for the prediction of prognosis and treatment selection.
- Subjects :
- Male
0301 basic medicine
Oncology
Cancer Research
lcsh:Medicine
Machine Learning
Prognostic markers
0302 clinical medicine
hemic and lymphatic diseases
Child
Promoter Regions, Genetic
lcsh:QH301-705.5
Aged, 80 and over
Leukemia
Methylation
Middle Aged
Prognosis
Gene Expression Regulation, Neoplastic
Child, Preschool
030220 oncology & carcinogenesis
DNA methylation
Female
Adult
Prognosis prediction
medicine.medical_specialty
Adolescent
Article
Young Adult
03 medical and health sciences
Myelogenous
Internal medicine
Acute lymphocytic leukemia
Biomarkers, Tumor
Genetics
medicine
Humans
Aged
Haematological cancer
business.industry
lcsh:R
Infant
DNA Methylation
medicine.disease
Highly sensitive
030104 developmental biology
lcsh:Biology (General)
Methylation profiling
CpG Islands
business
Subjects
Details
- ISSN :
- 20593635
- Volume :
- 5
- Database :
- OpenAIRE
- Journal :
- Signal Transduction and Targeted Therapy
- Accession number :
- edsair.doi.dedup.....66efd4611c9a81ef70b56939da0ec61d