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Transcranial magnetic stimulation over contralateral primary somatosensory cortex disrupts perception of itch intensity
- Source :
- Experimental Dermatology. 28:1380-1384
- Publication Year :
- 2018
- Publisher :
- Wiley, 2018.
-
Abstract
- Itch, a complex unpleasant sensation causing the desire to scratch, results from the activity of a network of brain regions. However, the specific functional contributions of individual regions within this network remain poorly understood. We investigated whether contralateral primary and secondary somatosensory cortices (S1, S2) and ipsilateral inferior frontal gyrus (IFG) are critically involved in the cortical processing of acute itch. Continuous theta burst transcranial magnetic stimulation (cTBS) was applied to either S1, S2 or IFG, followed by itch induction using a histamine prick. Results indicate a significant reduction in itch intensity when cTBS was applied to S1. Stimulation of S2 or the IFG was not associated with a significant reduction in itch intensity. The novel finding of an antipruritic effect elicited by disruption of activity in contralateral S1 suggests a causal role of S1 in encoding the sensory-discriminative aspect of itch and might be important in future studies on brain interventions for the treatment of itch.
- Subjects :
- Adult
Male
0301 basic medicine
medicine.medical_treatment
media_common.quotation_subject
CTBS
Prefrontal Cortex
Inferior frontal gyrus
Stimulation
Dermatology
Somatosensory system
Biochemistry
Young Adult
030207 dermatology & venereal diseases
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
immune system diseases
Perception
parasitic diseases
otorhinolaryngologic diseases
Humans
Medicine
skin and connective tissue diseases
Molecular Biology
media_common
business.industry
Pruritus
Antipruritic Effect
Somatosensory Cortex
Transcranial Magnetic Stimulation
eye diseases
Transcranial magnetic stimulation
030104 developmental biology
chemistry
Female
business
Neuroscience
Histamine
Subjects
Details
- ISSN :
- 16000625 and 09066705
- Volume :
- 28
- Database :
- OpenAIRE
- Journal :
- Experimental Dermatology
- Accession number :
- edsair.doi.dedup.....66eaf1452688e1ec6ce724d34bf0bfb5