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A Knockout Combo: Eradicating AML Stem Cells with TKI plus SIRT1 Inhibition
- Source :
- Cell Stem Cell. 15:395-397
- Publication Year :
- 2014
- Publisher :
- Elsevier BV, 2014.
-
Abstract
- SIRT1 inhibition facilitates elimination of CML stem cells by Imatinib, in part via p53 activation. In this issue of Cell Stem Cell, Li et al. (2014) demonstrate a similar role for SIRT1 inhibition in eradicating FLT3-ITD AML stem cells, potentially through a positive feedback loop with c-MYC, highlighting SIRT1 as a potential target in combination cancer therapy.
- Subjects :
- Myeloid
endocrine system diseases
Cell
Cancer
Imatinib
Cell Biology
Biology
medicine.disease
enzymes and coenzymes (carbohydrates)
Leukemia
medicine.anatomical_structure
Cancer stem cell
hemic and lymphatic diseases
Combination cancer therapy
Immunology
Genetics
medicine
Cancer research
Molecular Medicine
Stem cell
neoplasms
hormones, hormone substitutes, and hormone antagonists
medicine.drug
Subjects
Details
- ISSN :
- 19345909
- Volume :
- 15
- Database :
- OpenAIRE
- Journal :
- Cell Stem Cell
- Accession number :
- edsair.doi.dedup.....66e82179f8a2223c55ec122ae7493039