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Robust T Cell Response Toward Spike, Membrane, and Nucleocapsid SARS-CoV-2 Proteins Is Not Associated with Recovery in Critical COVID-19 Patients
- Source :
- Cell Reports Medicine, Vol 1, Iss 6, Pp 100092-(2020), Cell reports, 1(6):100092, Cell Reports. Medicine, Cell Reports Medicine
- Publication Year :
- 2020
- Publisher :
- Elsevier, 2020.
-
Abstract
- T cell immunity toward SARS-CoV-2 spike (S-), membrane (M-), and nucleocapsid (N-) proteins may define COVID-19 severity. Therefore, we compare the SARS-CoV-2-reactive T cell responses in moderate, severe, and critical COVID-19 patients and unexposed donors. Overlapping peptide pools of all three proteins induce SARS-CoV-2-reactive T cell response with dominance of CD4+ over CD8+ T cells and demonstrate interindividual immunity against the three proteins. M-protein induces the highest frequencies of CD4+ T cells, suggesting its relevance for diagnosis and vaccination. The T cell response of critical COVID-19 patients is robust and comparable or even superior to non-critical patients. Virus clearance and COVID-19 survival are not associated with either SARS-CoV-2 T cell kinetics or magnitude of T cell responses, respectively. Thus, our data do not support the hypothesis of insufficient SARS-CoV-2-reactive immunity in critical COVID-19. Conversely, it indicates that activation of differentiated memory effector T cells could cause hyperreactivity and immunopathogenesis in critical patients.<br />Graphical Abstract<br />Highlights M-, N-, and S-proteins induce T cell reactivity with differing immune dominance M-protein triggers a strong CD4+ T cell response ICU and non-ICU COVID-19 patients have comparable SARS-CoV-2 T cell responses Viral clearance and COVID-19 survival are not associated with SARS-CoV-2 immunity<br />Thieme et al. demonstrate the T cell response against M-, N-, and S-proteins of SARS-CoV-2, with M-protein triggering a stronger CD4+ T cell response. ICU COVID-19 patients are capable of generating functional SARS-CoV-2 immunity non-inferior to non-ICU COVID-19 patients. SARS-CoV-2 clearance and COVID-19 survival are not associated with the magnitude of T cell response.
- Subjects :
- Adult
Male
Coronavirus M Proteins
Critical Illness
T-Lymphocytes
viruses
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Medizin
nucleocapsid
Peptide
Biology
Article
General Biochemistry, Genetics and Molecular Biology
Virus
Immunity
Immunopathology
Coronavirus Nucleocapsid Proteins
Humans
immunopathology
Aged
S/M/N protein-reactive T cells
Aged, 80 and over
chemistry.chemical_classification
lcsh:R5-920
Effector
SARS-CoV-2
COVID-19
Convalescence
spike
biochemical phenomena, metabolism, and nutrition
Middle Aged
Phosphoproteins
immunity
critical COVID-19
Vaccination
chemistry
Spike Glycoprotein, Coronavirus
Immunology
Female
lcsh:Medicine (General)
CD8
Subjects
Details
- Language :
- English
- ISSN :
- 26663791
- Volume :
- 1
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Cell Reports Medicine
- Accession number :
- edsair.doi.dedup.....66e72ade8113f9c8d94eb2733c54e796