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Effect of volatile and total intravenous anesthesia on syndecan-1 shedding after minimally invasive gastrectomy: a randomized trial
- Source :
- Scientific Reports, Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
- Publication Year :
- 2021
- Publisher :
- Nature Publishing Group UK, 2021.
-
Abstract
- This study aimed to compare the effects of volatile anesthesia and total intravenous anesthesia (TIVA) on syndecan-1 shedding in patients with gastric cancer undergoing minimally invasive gastrectomy. Patients were randomly assigned to either the Volatile (n = 68) or the TIVA (n = 68) group. Anesthesia was maintained with sevoflurane/remifentanil or propofol/remifentanil in the Volatile and TIVA groups, respectively. Serum syndecan-1 was evaluated at pre-operation, end of operation, and postoperative day (POD) 1. Inflammatory markers including white blood cell (WBC) count, neutrophil-to-lymphocyte ratio (NLR), and C-reactive protein (CRP), were also measured at pre-operation, end of operation, and POD 1, 2, 3, and 5. The TIVA group showed significantly lower levels of syndecan-1 at the end of the operation compared to the Volatile group; however, no difference was seen between the groups at POD 1. The WBC count and NLR were significantly lower in the TIVA group at the end of the operation than the Volatile group, but there were no differences between the groups at POD 1, 2, 3, and 5. CRP levels were similar between the groups at all time points. In conclusion, despite TIVA being superior to volatile anesthesia in protecting endothelial glycocalyx during the operation, both did not prevent postoperative syndecan-1 shedding after gastrectomy.Clinical trial registration number: NCT04183296 (ClinicalTrial.gov, 03/12/2019).
- Subjects :
- Male
Science
medicine.medical_treatment
Remifentanil
Anesthesia, General
Sevoflurane
Article
law.invention
Syndecan 1
03 medical and health sciences
0302 clinical medicine
Randomized controlled trial
030202 anesthesiology
law
Stomach Neoplasms
White blood cell
medicine
Humans
Propofol
Aged
Multidisciplinary
business.industry
Gastroenterology
030208 emergency & critical care medicine
Middle Aged
Clinical trial
medicine.anatomical_structure
Anesthesia
Anesthesia Recovery Period
Anesthetics, Inhalation
Anesthesia, Intravenous
Medicine
Gastrectomy
Female
Syndecan-1
business
Anesthesia, Inhalation
Biomarkers
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....66e22a5d75f99dbdcd3b08d644fdb6a5