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Neuroepigenetic signatures of age and sex in the living human brain
- Source :
- Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019), Nature Communications
- Publication Year :
- 2019
- Publisher :
- Nature Portfolio, 2019.
-
Abstract
- Age- and sex-related alterations in gene transcription have been demonstrated, however the underlying mechanisms are unresolved. Neuroepigenetic pathways regulate gene transcription in the brain. Here, we measure in vivo expression of the epigenetic enzymes, histone deacetylases (HDACs), across healthy human aging and between sexes using [11C]Martinostat positron emission tomography (PET) neuroimaging (n = 41). Relative HDAC expression increases with age in cerebral white matter, and correlates with age-associated disruptions in white matter microstructure. A post mortem study confirmed that HDAC1 and HDAC2 paralogs are elevated in white matter tissue from elderly donors. There are also sex-specific in vivo HDAC expression differences in brain regions associated with emotion and memory, including the amygdala and hippocampus. Hippocampus and white matter HDAC expression negatively correlates with emotion regulation skills (n = 23). Age and sex are associated with HDAC expression in vivo, which could drive age- and sex-related transcriptional changes and impact human behavior.<br />Gene transcription is known to vary with age and sex, although the underlying mechanisms are unresolved. Here, the authors show that epigenetic enzymes known as HDACs, which regulate gene transcription, are increasingly expressed with age in the living human brain, with sex differences also observed.
- Subjects :
- Male
0301 basic medicine
Emotions
Histone Deacetylase 2
General Physics and Astronomy
Hippocampus
Adamantane
Histone Deacetylase 1
02 engineering and technology
Hydroxamic Acids
Epigenesis, Genetic
Carbon Radioisotopes
Epigenetics in the nervous system
lcsh:Science
Sex Characteristics
Martinostat
Multidisciplinary
biology
Histone deacetylase 2
Age Factors
Brain
Human brain
Middle Aged
021001 nanoscience & nanotechnology
White Matter
Tissue Donors
medicine.anatomical_structure
Histone
Female
0210 nano-technology
Sex characteristics
Adult
medicine.medical_specialty
Adolescent
Science
Article
General Biochemistry, Genetics and Molecular Biology
White matter
Young Adult
03 medical and health sciences
Internal medicine
medicine
Humans
Epigenetics
Aged
General Chemistry
030104 developmental biology
Endocrinology
biology.protein
lcsh:Q
Positron-emission tomography
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 10
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Nature Communications
- Accession number :
- edsair.doi.dedup.....66db91f6dcd6bbc9b339b5bacf19546d