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Efficient Catalytic Enantioselective Synthesis of Unsaturated Amines: Preparation of Small- and Medium-Ring Cyclic Amines through Mo-Catalyzed Asymmetric Ring-Closing Metathesis in the Absence of Solvent
- Source :
- Journal of the American Chemical Society. 124:6991-6997
- Publication Year :
- 2002
- Publisher :
- American Chemical Society (ACS), 2002.
-
Abstract
- The first catalytic asymmetric ring-closing metathesis method for the synthesis of N-containing heterocycles is reported; this is accomplished through Mo-catalyzed kinetic resolution or desymmetrization of unsaturated amines. Importantly, this catalytic asymmetric method delivers medium-ring unsaturated amines (including eight-membered rings) in high yield, with exceptional enantioselectivity and without the need for solvents. These enantioselective reactions can be effected by catalysts prepared in situ from commercially available reagents.
- Subjects :
- Molybdenum
Chemistry
Enantioselective synthesis
Hydrocarbons, Cyclic
Stereoisomerism
General Chemistry
Ring (chemistry)
Metathesis
Biochemistry
Desymmetrization
Catalysis
Kinetic resolution
Kinetics
Colloid and Surface Chemistry
Ring-closing metathesis
Organometallic Compounds
Solvents
Organic chemistry
Ring-opening metathesis polymerisation
Amines
Subjects
Details
- ISSN :
- 15205126 and 00027863
- Volume :
- 124
- Database :
- OpenAIRE
- Journal :
- Journal of the American Chemical Society
- Accession number :
- edsair.doi.dedup.....66d3ea734034ea6cb5059e20668f92bd