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Towards Clinical Implementation of Adeno-Associated Virus (AAV) Vectors for Cancer Gene Therapy: Current Status and Future Perspectives
- Source :
- Cancers, Vol 12, Iss 1889, p 1889 (2020), Cancers
- Publication Year :
- 2020
- Publisher :
- MDPI AG, 2020.
-
Abstract
- Adeno-associated virus (AAV) vectors have gained tremendous attention as in vivo delivery systems in gene therapy for inherited monogenetic diseases. First market approvals, excellent safety data, availability of large-scale production protocols, and the possibility to tailor the vector towards optimized and cell-type specific gene transfer offers to move from (ultra) rare to common diseases. Cancer, a major health burden for which novel therapeutic options are urgently needed, represents such a target. We here provide an up-to-date overview of the strategies which are currently developed for the use of AAV vectors in cancer gene therapy and discuss the perspectives for the future translation of these pre-clinical approaches into the clinic.
- Subjects :
- 0301 basic medicine
Tumor angiogenesis
Cancer Research
CAR-T cells
Genetic enhancement
adeno-associated virus (AAV) vectors
Gene transfer
Review
Computational biology
medicine.disease_cause
lcsh:RC254-282
03 medical and health sciences
0302 clinical medicine
vaccine
Medicine
Vector (molecular biology)
transductional targeting
Adeno-associated virus
business.industry
apoptosis
Cancer
tumor angiogenesis
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
medicine.disease
transcriptional targeting
030104 developmental biology
Oncology
030220 oncology & carcinogenesis
Cancer gene
immunotherapy
Car t cells
business
hallmarks of cancer
Subjects
Details
- ISSN :
- 20726694
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Cancers
- Accession number :
- edsair.doi.dedup.....66c4c932399b8406d91a9b82b408842f