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Interactions Between Diet Quality and Interleukin-6 Genotypes Are Associated With Metabolic and Renal Function Parameters in Mexican Patients With Type 2 Diabetes Mellitus
- Source :
- Journal of Renal Nutrition. 30:223-231
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- Objective The aim of this study was to evaluate the interaction between diet quality and interleukin (IL)-6 genotypes and its association with metabolic and renal function parameters in Mexican patients with type 2 diabetes mellitus (T2DM). Design and Methods Using an analytical cross-sectional design, 219 patients with T2DM (92 men; age 62 ± 10 years) were evaluated for selected metabolic and renal function parameters. Diet quality according to the Healthy Eating Index was evaluated and classified as good diet or poor diet in all patients. IL-6 serum concentrations and genotypes and haplotypes for IL6–597G > A (rs180097), –572G > C (rs180096), and –174G > C (rs180095) polymorphisms were determined. Results Eighty-two percent of patients reported having a poor diet. Carriers of alleles –572C and –174C showed higher high-density lipoprotein cholesterol levels (44 ± 12 vs. 40 ± 9 mg/dL; P = .01) and lower total cholesterol levels (184 ± 33 vs. 197 ± 42 mg/dL; P = .03) than did those homozygous for G/G. Neither IL6 genotypes nor haplotypes were significantly associated with serum concentrations of IL-6. Some significant interactions between IL6 genotypes/haplotypes and diet quality were associated with body mass index, waist circumference, high-density lipoprotein cholesterol levels, and estimated glomerular filtration rate. Conclusions Interactions between diet quality and IL6 genotypes/haplotypes were associated with the main metabolic and renal function parameters in Mexican patients with T2DM. It will be important to consider genetic profiles in designing dietary portfolios and nutritional interventions for the management of such patients.
- Subjects :
- Male
0301 basic medicine
medicine.medical_specialty
Waist
Genotype
030232 urology & nephrology
Medicine (miscellaneous)
Renal function
Kidney
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Humans
Allele
Mexico
Polymorphism, Genetic
030109 nutrition & dietetics
Nutrition and Dietetics
Interleukin-6
business.industry
Haplotype
Type 2 Diabetes Mellitus
Interleukin
Middle Aged
Diet
Cholesterol
Cross-Sectional Studies
Endocrinology
Diabetes Mellitus, Type 2
Nephrology
Female
business
Body mass index
Subjects
Details
- ISSN :
- 10512276
- Volume :
- 30
- Database :
- OpenAIRE
- Journal :
- Journal of Renal Nutrition
- Accession number :
- edsair.doi.dedup.....66c03d29af86a9c8d0a24d7490320b56