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A gene dysfunction module reveals the underlying pathogenesis of hidradenitis suppurativa: An update
- Source :
- The Australasian journal of dermatologyReferences. 61(1)
- Publication Year :
- 2019
-
Abstract
- Hidradenitis suppurativa is a chronic skin disease characterised by repeated skin abscesses with sinus tracts and scar formation. Currently, the aetiology and pathogenesis of hidradenitis suppurativa remain unclear. Genetic factors, immune disorders, hormonal abnormalities, skin-microbial dysbiosis, smoking, obesity and mechanical friction all influence hidradenitis suppurativa pathogenesis. Moreover, hidradenitis suppurativa has a familial subset with autosomal dominant transmission proposed and is related to a mutation of γ-secretase component genes. In this review, we analyse and summarise research progress regarding the relationship between the γ-secretase gene dysfunction and the pathogenesis of hidradenitis suppurativa.
- Subjects :
- medicine.medical_specialty
integumentary system
business.industry
Dermatology
Gene mutation
medicine.disease
Autosomal dominant transmission
Hidradenitis Suppurativa
Pathogenesis
030207 dermatology & venereal diseases
03 medical and health sciences
Skin Abscess
0302 clinical medicine
030220 oncology & carcinogenesis
Etiology
Medicine
Humans
Hidradenitis suppurativa
Amyloid Precursor Protein Secretases
business
Gene
Dysbiosis
Subjects
Details
- ISSN :
- 14400960
- Volume :
- 61
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- The Australasian journal of dermatologyReferences
- Accession number :
- edsair.doi.dedup.....66b538583b402387d16e4326fb36df3e