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Stress-Induced Memory Retrieval Impairments: Different Time-Course Involvement of Corticosterone and Glucocorticoid Receptors in Dorsal and Ventral Hippocampus
- Source :
- Neuropsychopharmacology
- Publication Year :
- 2012
- Publisher :
- Springer Science and Business Media LLC, 2012.
-
Abstract
- The present study was aimed at determining the relative contribution of the dorsal (DH) and ventral (VH) hippocampus in stress-induced memory retrieval impairments. Thus, we studied the temporal involvement of corticosterone and its receptors, i.e. mineralocorticoid (MR) and glucocorticoid (GR) in the DH and VH, in relation with the time-course evolution of stress-induced memory retrieval impairments. In a first experiment, double microdialysis allowed showing on the same animal that an acute stress (electric footshocks) induced an earlier corticosterone rise in the DH (15-60 min post-stress) and then in the VH (90-105 min post-stress). The return to baseline was faster in the DH (105 min) than in the VH (120 min). Memory deficits assessed by delayed alternation occurred at 15-, 60-, and 105-min delays after stress and were closely related to the kinetic of corticosterone rises within the DH and VH. In a second experiment, the GR antagonist RU-38486 and the MR antagonist RU-28318 were administered in the DH or VH 15 min before stress. RU-38486 restored memory at 60 but not at 105 min post-stress delays in the DH, whereas the opposite pattern was observed in the VH. By contrast, RU-28318 had no effect on memory impairments at both the 60- and 105-min post-stress delays, showing that MR receptors are not involved at these delays. However, RU-28318 administered in the DH restored memory when administered at a shorter post-stress delay (15 min). Overall, our data are first to evidence that stress induces a functional switch from the DH to VH via different corticosterone time-course evolutions in these areas and the sequential GR receptors involvement in the DH and then in the VH, as regards the persistence of stress-induced memory retrieval deficits over time.
- Subjects :
- Male
medicine.medical_specialty
Microdialysis
Time Factors
microdialysis
hippocampus
medicine.drug_class
Hippocampus
behavioral science
neuropharmacology
stress
Mice
chemistry.chemical_compound
Receptors, Glucocorticoid
Glucocorticoid receptor
Corticosterone
Internal medicine
medicine
learning & memory
Animals
Receptor
Pharmacology
Memory Disorders
mood/anxiety/stress disorders
corticosterone
Antagonist
glucocorticoid MR and GR receptors
Mice, Inbred C57BL
Psychiatry and Mental health
Endocrinology
chemistry
Mineralocorticoid
memory-corticosterone
Original Article
Psychology
dorsal and ventral hippocampus
Stress, Psychological
Glucocorticoid
medicine.drug
Subjects
Details
- ISSN :
- 1740634X and 0893133X
- Volume :
- 37
- Database :
- OpenAIRE
- Journal :
- Neuropsychopharmacology
- Accession number :
- edsair.doi.dedup.....66902af81f49c8fb33340db6a46379e0