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Multiple SARS-CoV-2 introductions shaped the early outbreak in Central Eastern Europe: comparing Hungarian data to a worldwide sequence data-matrix
- Source :
- Viruses, Volume 12, Issue 12, Viruses, Vol 12, Iss 1401, p 1401 (2020)
- Publication Year :
- 2020
- Publisher :
- Cold Spring Harbor Laboratory, 2020.
-
Abstract
- Severe Acute Respiratory Syndrome Coronavirus 2 is the third highly pathogenic human coronavirus in history. Since the emergence in Hubei province, China, during late 2019 the situation evolved to pandemic level. Following China, Europe was the second epicenter of the pandemic. To better comprehend the detailed founder mechanisms of the epidemic evolution in Central-Eastern Europe, particularly in Hungary, we determined the full-length SARS-CoV-2 genomes from 32 clinical samples collected from laboratory confirmed COVID-19 patients over the first month of disease in Hungary. We applied a haplotype network analysis on all available complete genomic sequences of SARS-CoV-2 from GISAID database as of the 21th of April, 2020. We performed additional phylogenetic and phylogeographic analyses to achieve the recognition of multiple and parallel introductory events into our region. Here we present a publicly available network imaging of the worldwide haplotype relations of SARS-CoV-2 sequences and conclude the founder mechanisms of the outbreak in Central-Eastern Europe.
- Subjects :
- 0106 biological sciences
0301 basic medicine
China
Central eastern europe
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
lcsh:QR1-502
Oropharynx
Genome, Viral
010603 evolutionary biology
01 natural sciences
lcsh:Microbiology
Article
Disease Outbreaks
03 medical and health sciences
Data sequences
Virology
Pandemic
Humans
Gene Regulatory Networks
Europe, Eastern
network analysis
human coronavirus
Hungary
Phylogenetic tree
outbreak
SARS-CoV-2
pandemic
Haplotype
Outbreak
COVID-19
Sequence Analysis, DNA
phylodynamics
Europe
Phylogeography
030104 developmental biology
Infectious Diseases
Geography
Evolutionary biology
RNA, Viral
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Viruses, Volume 12, Issue 12, Viruses, Vol 12, Iss 1401, p 1401 (2020)
- Accession number :
- edsair.doi.dedup.....667bbf409f556dfc6b7f0c62176234ef
- Full Text :
- https://doi.org/10.1101/2020.05.06.080119