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Enhanced release of ammonia and hypoxanthine from exercising muscles in patients with idiopathic hypoparathyroidism
- Source :
- Musclenerve. 10(7)
- Publication Year :
- 1987
-
Abstract
- Semiischemic forearm exercise tests were carried out in two patients with idiopathic hypoparathyroidism who had muscle cramps and high serum levels of creatine kinase. Although cubital venous lactate levels increased normally after forearm exercise, venous ammonia and hypoxanthine were greatly increased. The abnormal responses of ammonia and hypoxanthine were normalized 3 months after treatment with 1 alpha-hydroxyvitamin D3. These findings suggest that excess purine degradation occurred in exercising muscles of patients with idiopathic hypoparathyroidism.
- Subjects :
- Purine
Adult
Male
medicine.medical_specialty
Physiology
Hypoparathyroidism
Physical Exertion
Physical exercise
Cellular and Molecular Neuroscience
chemistry.chemical_compound
Ammonia
Forearm
Physiology (medical)
Internal medicine
medicine
Humans
Hypoxanthine
biology
business.industry
Muscles
medicine.disease
medicine.anatomical_structure
Endocrinology
chemistry
Purines
Hypoxanthines
biology.protein
Lactates
Creatine kinase
Female
Neurology (clinical)
medicine.symptom
business
Muscle cramp
Subjects
Details
- ISSN :
- 0148639X
- Volume :
- 10
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Musclenerve
- Accession number :
- edsair.doi.dedup.....66789ae60bbea49563a1acfdaccc2162