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Environmental estrogenic pollutants induce acute vascular relaxation by inhibiting L-type Ca2+ channels in smooth muscle cells
- Source :
- Europe PubMed Central
-
Abstract
- There is an ongoing scientific debate concerning the potential threat of environmental estrogenic pollutants to animal and human health (1-5). Pollutants including the detergents 4-octylphenol and p-nonylphenol and chlorinated insecticides have recently been reported to modulate sexual differentiation by interacting with nuclear steroid receptors (6-8). So far, the focus has been on reproductive organs, but sex steroids have far more widespread actions. The lower incidence of cardiovascular disease in women has been attributed to estrogens (9-14), yet no information is available on the vascular actions of environmental estrogenic pollutants. In the present study we have investigated the effects of acute exposure to 17beta-estradiol, the antiestrogen ICI 182,780, and estrogenic pollutants on coronary vascular tone as well as on intracellular Ca2+ levels ([Ca2+]i) and Ca2+ and K+ channel activity in vascular smooth muscle cells. We report here that 4-octylphenol, p-nonylphenol, o.p'-DDT, and the antiestrogen ICI 182,780 inhibit L-type Ca2+ channels in vascular smooth muscle cells and evoke a rapid and endothelium-independent relaxation of the coronary vasculature similar to that induced by 17beta-estradiol. Thus, inhibition of Ca2+ influx via L-type Ca2+ channels in vascular smooth muscle cells may explain the acute, nongenomic vasodilator actions of environmental estrogenic pollutants.
- Subjects :
- Male
Insecticides
Potassium Channels
Calcium Channels, L-Type
medicine.drug_class
Muscle Relaxation
Biochemistry
Muscle, Smooth, Vascular
Rats, Sprague-Dawley
03 medical and health sciences
chemistry.chemical_compound
Human health
0302 clinical medicine
Phenols
Smooth muscle
Genetics
medicine
Animals
Humans
Fulvestrant
Molecular Biology
030304 developmental biology
Pollutant
0303 health sciences
Estradiol
Relaxation (psychology)
Estrogen Antagonists
Estrogens
L type ca2 channels
Calcium Channel Blockers
Antiestrogen
Coronary Vessels
Rats
3. Good health
Nonylphenol
chemistry
13. Climate action
Estrogen
Biophysics
Environmental Pollutants
Female
Calcium Channels
030217 neurology & neurosurgery
Biotechnology
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Europe PubMed Central
- Accession number :
- edsair.doi.dedup.....6669cfb1c7f501d6a4519a142202bde5