Oxotremorine antagonism by a hypothalamic hormone, melanocyte-stimulating hormone release-inhibiting factor (MIF)

SummaryMIF was demonstrated to antagonize the central and peripheral effects of oxotremorine in normal as well as in hypophysectomized mice. Its effectiveness in hypophysectomized mice confirms our earlier report that MIF exerts actions upon the CNS which are independent of its MSH release-inhibiting activity.The authors thank Dr. E. Kimura and Mr. P. Young for the anticholinergic studies in the isolated guinea pig ileum.