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In vivo evaluation of corneal biomechanical properties by optical coherence elastography at different cross-linking irradiances
- Source :
- Journal of Biomedical Optics
- Publication Year :
- 2019
- Publisher :
- SPIE-Intl Soc Optical Eng, 2019.
-
Abstract
- Corneal collagen cross-linking (CXL) strengthens the biomechanical properties of damaged corneas. Quantifying the changes of stiffness due to different CXL protocols is difficult, especially in vivo. A noninvasive elastic wave-based optical coherence elastography system was developed to construct in vivo corneal elasticity maps by excitation of air puff. Biomechanical differences were compared for rabbit corneas given three different CXL protocols while keeping the total energy delivered constant. The Young’s modulus was weaker in corneas treated with higher irradiance levels over shorter durations, and a slight increase of Young’s modulus was present in all groups one week after the recovery process. Due to the noninvasive nature and minimal force to generate corneal elastic waves, this technique has the potential for early detection and treatment of corneal diseases in clinic.
- Subjects :
- Paper
Male
Materials science
Biomedical Engineering
Early detection
01 natural sciences
Cornea
010309 optics
Biomaterials
Optical coherence elastography
Optical coherence tomography
In vivo
Elastic Modulus
0103 physical sciences
medicine
Animals
General
optical coherence elastography
medicine.diagnostic_test
Corneal Diseases
Stiffness
Equipment Design
eye diseases
Atomic and Molecular Physics, and Optics
Electronic, Optical and Magnetic Materials
in vivo
medicine.anatomical_structure
Elasticity Imaging Techniques
Collagen
Rabbits
sense organs
Elastography
medicine.symptom
collagen cross-linking
Tomography, Optical Coherence
Biomedical engineering
Subjects
Details
- ISSN :
- 10833668
- Volume :
- 24
- Database :
- OpenAIRE
- Journal :
- Journal of Biomedical Optics
- Accession number :
- edsair.doi.dedup.....6664f6565929cfbd36c35a752f7a7c20