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Treatment of canine pyoderma with ibafloxacin and marbofloxacin--fluoroquinolones with different pharmacokinetic profiles
- Source :
- Journal of veterinary pharmacology and therapeutics. 27(3)
- Publication Year :
- 2004
-
Abstract
- Dogs with superficial or deep pyoderma (n = 228) presented to first opinion veterinarians (n = 20) were treated orally with either ibafloxacin, at a dosage of 15 mg/kg, or marbofloxacin, at a dosage of 2 mg/kg, once daily for 3-16 weeks. On initial presentation, 35% of the cases were classified as having recurrent pyoderma and 40% as having deep pyoderma. Staphylococci (mainly Staphylococcus intermedius) were isolated from over 90% of the cases. The average treatment periods were 41 +/- 26 and 38 +/- 21 days in the ibafloxacin and marbofloxacin groups, respectively. One week after the cessation of treatment, 74 and 81% of dogs (P > 0.05) in the ibafloxacin and marbofloxacin groups, respectively, were classified as having responded to treatment. One month after the cessation of treatment, 70% of the dogs in each group were still classified as cured or improved, and 3 and 11% (P < 0.05) in the ibafloxacin and marbofloxacin groups, respectively, were classified as having relapsed. Despite having different pharmacokinetic profiles, ibafloxacin and marbofloxacin produced similar results when used under field conditions at the recommended dosages.
- Subjects :
- Veterinary medicine
medicine.medical_specialty
Dose
Pyoderma
Administration, Oral
Quinolones
Gastroenterology
Severity of Illness Index
Drug Administration Schedule
Dogs
Marbofloxacin
Pharmacokinetics
Internal medicine
medicine
Animals
Dog Diseases
Pharmacology
General Veterinary
biology
Staphylococcus intermedius
business.industry
Ibafloxacin
Veterinary Drugs
medicine.disease
biology.organism_classification
Europe
Treatment Outcome
Once daily
business
Quinolizines
medicine.drug
Field conditions
Fluoroquinolones
Subjects
Details
- ISSN :
- 01407783
- Volume :
- 27
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Journal of veterinary pharmacology and therapeutics
- Accession number :
- edsair.doi.dedup.....6661a250796bc08c79ae572414bd32c9