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Suite PET/CT neuroimaging for the diagnosis of Parkinson’s disease
- Source :
- Nuclear Medicine Communications. 38:164-169
- Publication Year :
- 2017
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2017.
-
Abstract
- The aim of this study was to investigate the topographical distribution of dopamine transporter (DAT), dopamine D2 receptor, and glucose metabolism in Parkinson's disease (PD) using PET/computed tomography (CT) scanning and statistical parametric mapping (SPM) analysis.Seventy-four patients (58 PD patients and 16 normal controls) underwent DAT, D2 receptor, and glucose brain PET/CT scans using C-methyl-N-2-β-carbomethoxy-3-β-(4-fluorophenyl) tropane (C-β-CFT), C-raclopride (C-RAC), and fluorine-18-fluorodeoxyglucose (F-FDG) radiotracers for the respective scans. All three PET/CT procedures were performed in each participant. The uptake patterns were analyzed using SPM software.Striatal DAT binding was lower in PD patients than in controls, whereas D2 receptor binding did not differ between PD patients and controls. D2 receptor binding was increased in the putamen in only the 12 drug-naive patients. Glucose uptake was also slightly lower in the cingulate gyrus of PD patients than in the controls.Suite PET/CT scans using the ligands C-β-CFT, C-RAC, and F-FDG PET/CT are valuable for diagnosing PD. SPM-based analysis of static PET/CT scan data is potentially of great clinical use.
- Subjects :
- Adult
Male
medicine.medical_specialty
Parkinson's disease
Computed tomography
Statistical parametric mapping
030218 nuclear medicine & medical imaging
Young Adult
03 medical and health sciences
0302 clinical medicine
Cocaine
Neuroimaging
Fluorodeoxyglucose F18
Positron Emission Tomography Computed Tomography
Dopamine receptor D2
medicine
Humans
Radiology, Nuclear Medicine and imaging
Aged
Dopamine transporter
Aged, 80 and over
Raclopride
Brain Mapping
Dopamine Plasma Membrane Transport Proteins
PET-CT
medicine.diagnostic_test
biology
Receptors, Dopamine D2
business.industry
Functional Neuroimaging
Brain
Parkinson Disease
General Medicine
Middle Aged
medicine.disease
Molecular Imaging
Glucose
Case-Control Studies
biology.protein
Female
Radiology
Radiopharmaceuticals
Nuclear medicine
business
030217 neurology & neurosurgery
medicine.drug
Subjects
Details
- ISSN :
- 01433636
- Volume :
- 38
- Database :
- OpenAIRE
- Journal :
- Nuclear Medicine Communications
- Accession number :
- edsair.doi.dedup.....665aec6cc6e026464f0d11f473b40b84