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Analysis of the V3 loop sequences from 10 HIV type 1-infected AIDS patients from Paraguay
- Source :
- AIDS research and human retroviruses. 11(9)
- Publication Year :
- 1995
-
Abstract
- HIV-1 consists of eight subtypes, A through H, and group O. The HIV epidemic has only recently come to Paraguay. According to available data from the National AIDS Control Program of Paraguay, there were only 95 individuals known to have had AIDS in the country by the end of 1994. The authors report their findings from the study of HIV-1 from ten people with AIDS living in Asuncion. The subjects were male, with AIDS-related symptoms, and largely contracted HIV through homosexual contact. Some, however, contracted HIV through IV drug use or heterosexually. The nucleic acid sequences obtained from the collected viruses grown in tissue culture have been deposited in GenBank under accession numbers U28949 through U28959. All of the isolated viruses are of subtype B. Virus PY.3616, however, had a V3 loop with the rare motif APGR. The individual from whom this virus was obtained acquired his HIV infection through IV drug use, most probably in Argentina. Two viruses were obtained with V3 loop crown motifs of GPRR and GWRR (PY.12838 and PY.12839), motifs which have not been previously described, but which come close to the V3 loops of HIV-1 isolates found in Brazil with a crown motif GWGR, and also GMGR and GFGR. A motif with an arginine at another position, GRGQ, has been found in HIV-1 subtype H in Cameroon. The different motifs found in the sequences of the Paraguayan patients show greater homogeneity than those of African patients in the Central African Republic and in Paris. The observed diversity reflects the connection of Paraguayans with Brazil and other countries where HIV-1 subtype B prevails. The authors note that their findings are most likely representative of the ongoing, young HIV epidemic in Paraguay.
- Subjects :
- Male
Immunology
Molecular Sequence Data
Human immunodeficiency virus (HIV)
V3 loop
Biology
HIV Envelope Protein gp120
medicine.disease_cause
Virus
Acquired immunodeficiency syndrome (AIDS)
Virology
medicine
Cluster Analysis
Humans
Amino Acid Sequence
Sida
DNA Primers
Acquired Immunodeficiency Syndrome
Base Sequence
Sequence Homology, Amino Acid
Nucleic acid sequence
medicine.disease
biology.organism_classification
Peptide Fragments
Infectious Diseases
Paraguay
GenBank
DNA, Viral
HIV-1
Viral disease
Subjects
Details
- ISSN :
- 08892229
- Volume :
- 11
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- AIDS research and human retroviruses
- Accession number :
- edsair.doi.dedup.....66598b367af81005c3c5c25d371dd8cd