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CONTRIBUTION OF SYMPATHO-ADRENAL SYSTEM TO THE GASTRIC MOVEMENT OF RATS SUBJECTED TO RESTRAINT AND WATER IMMERSION STRESS
- Source :
- Japanese Journal of Pharmacology. 27:635-643
- Publication Year :
- 1977
- Publisher :
- Elsevier BV, 1977.
-
Abstract
- Exposure of the rat to restraint and water immersion stress enhanced a characteristic gastric movement in a 2- to 4-hr latent period. The mechanism of producing such gastric movement was studied in connection with changes in the sympatho-adrcnal activity. Acute bilateral adrenalectomy and reserpine pretreatment significantly hastened occurrence of the gastric movement and guanethidine pretreatment showed a similar tendency. Epinephrine content in the adrenals of the stressed group markedly decreased at the time of occurrence of the gastric movement. Urinary excretion of epinephrine and norepinephrine continued to increase for 3 hr and for 6 hr respectively, after the onset of stress, and both excretory rates declined thereafter. Epinephrine and norepinephrine were much more effective on depressing the stress-induced gastric movement than cortisone and ACTH. It was suggested that: 1) at the initial stage of stress, the adrenal function as well as the sympathetic nervous function was activated, and a large amount of epinephrine and norepinephrine was secreted, which brought about an inhibition of the gastric movement; 2) at the subsequent stage, the parasympathetic nervous function became more prominent than the sympathoadrenal one and initiated the gastric movement; and 3) contribution of corticosteroids and/or ACTH to the gastric movement was small, if any.
- Subjects :
- Guanethidine
Male
Restraint, Physical
medicine.medical_specialty
Reserpine
Sympathetic Nervous System
Time Factors
Epinephrine
Norepinephrine
Adrenocorticotropic Hormone
Stress, Physiological
Internal medicine
Adrenal Glands
Immersion
medicine
Animals
Adrenal function
Tissue Distribution
Pharmacology
business.industry
Adrenalectomy
Stimulation, Chemical
Rats
Cortisone
Endocrinology
Water immersion
Excretory system
Depression, Chemical
Gastrointestinal Motility
business
medicine.drug
Subjects
Details
- ISSN :
- 00215198
- Volume :
- 27
- Database :
- OpenAIRE
- Journal :
- Japanese Journal of Pharmacology
- Accession number :
- edsair.doi.dedup.....66553bfb80e24b578e27404a06cdfa70