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Pandemic A/H1N1(2009) Influenza Infections in Very-Low-Birth-Weight Infants – a Case Series from the German Neonatal Network
- Source :
- Klinische Pädiatrie. 223:267-270
- Publication Year :
- 2011
- Publisher :
- Georg Thieme Verlag KG, 2011.
-
Abstract
- 6 cases of clinical influenza A/H1N1(2009) infections were reported within the multi-center German Neonatal Network (GNN) during the primary hospital stay in the pandemic season 2009/2010 and 2010/2011. Clinical symptoms varied from transient hyperthermia to apnea and severe respiratory distress. 1 fatal course with systemic inflammatory response after perinatal transmission of A/H1N1(2009) was observed. Oseltamivir treatment in 3/6 infants was without side effects. The reported cases have major implications for the management of VLBW infants: i) fatal courses after perinatal transmission are possible, ii) postnatal A/H1N1(2009) infection may result in life threatening events at a time when the infant is otherwise stable, iii) vaccination should be recommended for parents and medical staff to avoid nosocomial transmission, iv) more data are needed on the benefit and harm of antiviral drugs in preterm infants, v) neonatologists should suspect A/H1N1(2009) infection when unexplained sepsis-like or respiratory symptoms occur in VLBW infants.
- Subjects :
- Male
Oseltamivir
Pediatrics
medicine.medical_specialty
Pneumonia, Viral
Medizin
Gestational Age
Infant, Premature, Diseases
Antiviral Agents
Diagnosis, Differential
Sepsis
chemistry.chemical_compound
Influenza A Virus, H1N1 Subtype
Risk Factors
Cause of Death
Germany
Influenza, Human
Pandemic
medicine
Humans
Infant, Very Low Birth Weight
Cause of death
Cross Infection
Respiratory Distress Syndrome, Newborn
Respiratory distress
business.industry
Infant, Newborn
Apnea
medicine.disease
Survival Rate
Vaccination
Low birth weight
chemistry
Infant, Extremely Low Birth Weight
Pediatrics, Perinatology and Child Health
Female
medicine.symptom
business
Subjects
Details
- ISSN :
- 14393824 and 03008630
- Volume :
- 223
- Database :
- OpenAIRE
- Journal :
- Klinische Pädiatrie
- Accession number :
- edsair.doi.dedup.....66539f27832e72f312d8cad50eac1141