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Interaction of lipophilic peptides derived from mastoparan with phospholipid vesicles
- Source :
- Scopus-Elsevier
- Publication Year :
- 2009
- Publisher :
- Wiley, 2009.
-
Abstract
- Various kinds of lipophilic peptides were prepared by acylation of an alpha-helical peptide, mastoparan, to investigate the effects of acyl groups on the interaction of peptides with phospholipid membranes. alpha-Helicity of the peptides was increased by introduction of long acyl groups. Acyl peptides showed different membrane-perturbation activities for neutral and acidic phospholipid vesicles, whereas a peptide with a dialkycarbamoyl group always exhibited a strong activity. High hemolytic activities were observed for the peptides with long acyls (single or double chain). These results indicate that lipophilic groups introduced to mastoparan contribute greatly to the interaction of the peptide with phospholipid membranes with lengthening of the acyl chain and that the structural character of the lipophilic group also influences the conformation of the peptide.
- Subjects :
- Phospholipid vesicles
1,2-Dipalmitoylphosphatidylcholine
Acylation
Phospholipid
Wasp Venoms
Peptide
Hemolysis
Biochemistry
Protein Structure, Secondary
Membrane Lipids
Structure-Activity Relationship
chemistry.chemical_compound
Endocrinology
medicine
Phospholipids
chemistry.chemical_classification
Circular Dichroism
Phosphatidylglycerols
medicine.disease
Membrane
chemistry
Drug Design
Acyl chain
Mastoparan
Liposomes
Intercellular Signaling Peptides and Proteins
lipids (amino acids, peptides, and proteins)
Peptides
Subjects
Details
- ISSN :
- 1397002X
- Volume :
- 50
- Database :
- OpenAIRE
- Journal :
- The Journal of Peptide Research
- Accession number :
- edsair.doi.dedup.....664f41ae222033807662c72fa55d9b86