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Correlation between Endothelial Dysfunction, Rho-associated Protein Kinase Activity, C-reactive Protein and Obstructive Sleep Apnoea Syndrome in Male Patients
- Source :
- Journal of International Medical Research. 40:2183-2190
- Publication Year :
- 2012
- Publisher :
- SAGE Publications, 2012.
-
Abstract
- Objective: This study investigated the association between obstructive sleep apnoea syndrome (OSAS) and flow-mediated dilatation (FMD), Rho-associated protein kinase (ROCK) activity, and C-reactive protein (CRP) concentrations in male patients. Methods: Consecutive patients with symptoms suggestive of OSAS were recruited and divided into non-OSAS (n = 18) and OSAS (n = 32) groups. FMD was measured in the brachial artery; blood samples were taken to measure ROCK activity and CRP concentrations. Results: ROCK activity and CRP concentrations were significantly higher, and FMD was significantly lower, in the OSAS group than in the non-OSAS group. There was a correlation between ROCK activity and FMD. In stepwise multiple regression analyses, the proportion of sleep time spent with an oxygen saturation < 90% was a significant determinant of ROCK activity, while body mass index was the only significant determinant of CRP concentration. The oxygen desaturation index was a significant determinant of FMD. Conclusions: OSAS increased ROCK activity and was a major determinant of endothelial dysfunction.
- Subjects :
- Male
medicine.medical_specialty
Brachial Artery
Endothelium
Polysomnography
Blood Pressure
Biochemistry
Gastroenterology
Body Mass Index
Sleep Apnea Syndromes
stomatognathic system
medicine.artery
Internal medicine
medicine
Humans
Brachial artery
Endothelial dysfunction
Oxygen saturation (medicine)
rho-Associated Kinases
medicine.diagnostic_test
biology
business.industry
Biochemistry (medical)
C-reactive protein
Cell Biology
General Medicine
Middle Aged
medicine.disease
Oxygen
C-Reactive Protein
Blood pressure
medicine.anatomical_structure
biology.protein
Endothelium, Vascular
business
Body mass index
Blood Flow Velocity
Subjects
Details
- ISSN :
- 14732300 and 03000605
- Volume :
- 40
- Database :
- OpenAIRE
- Journal :
- Journal of International Medical Research
- Accession number :
- edsair.doi.dedup.....663edbb1556f84ee94f71cd5a9feec1f